SPECIAL MEDICAL EDITORIALS:

Stuart J. Moat, Sagar N. Doshi, Derek Lang, Ian F. W. McDowell, Malcolm J. Lewis, and Jonathan Goodfellow

Treatment of coronary heart disease with folic acid: is there a future?
Am J Physiol Heart Circ Physiol 287: H1-H7, 2004; doi:10.1152/ajpheart.00952.2003 [Full Text] [PDF]  

INVITED REVIEW: POINT-COUNTERPOINT:

Walter J. Paulus and Jean G. F. Bronzwaer

Nitric oxide's role in the heart: control of beating or breathing?
Am J Physiol Heart Circ Physiol 287: H8-H13, 2004; doi:10.1152/ajpheart.01147.2003 [Abstract] [Full Text] [PDF]  

Alexandra Adler, Harer Huang, Zipping Wang, Joseph Conetta, Ellen Levee, Xiaoping Zhang, and Thomas H. Hintze

Endocardial endothelium in the avascular frog heart: role for diffusion of NO in control of cardiac O₂ consumption
Am J Physiol Heart Circ Physiol 287: H14-H21, 2004; doi:10.1152/ajpheart.01235.2003 [Abstract] [Full Text] [PDF]  

ARTICLES:

Sabena Sultan, Martin Gosling, Shadi Abu-Hayyeh, Nessa Carey, and Janet T. Powell

Flow-dependent increase of ICAM-1 on saphenous vein endothelium is sensitive to apamin
Am J Physiol Heart Circ Physiol 287: H22-H28, 2004. First published February 12, 2004; doi:10.1152/ajpheart.00880.2003 [Abstract] [Full Text] [PDF]  

Weike Mao, Fuzhong Qin, Chikao Iwai, Raju Vulapalli, Peter C. Keng, and Chang-seng Liang

Extracellular norepinephrine reduces neuronal uptake of norepinephrine by oxidative stress in PC12 cells
Am J Physiol Heart Circ Physiol 287: H29-H39, 2004. First published February 12, 2004; doi:10.1152/ajpheart.01168.2003 [Abstract] [Full Text] [PDF]  

Sukrutha Veerareddy, Christy-Lynn M. Cooke, Philip N. Baker, and Sandra T. Davidge

Gender differences in myogenic tone in superoxide dismutase knockout mouse: animal model of oxidative stress
Am J Physiol Heart Circ Physiol 287: H40-H45, 2004. First published February 19, 2004; doi:10.1152/ajpheart.01179.2003 [Abstract] [Full Text] [PDF]  

Candace D. Gildner, Amy L. Lerner, and Denise C. Hocking

Fibronectin matrix polymerization increases tensile strength of model tissue
Am J Physiol Heart Circ Physiol 287: H46-H53, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00859.2003 [Abstract] [Full Text] [PDF]  

Daisuke Yamashita, Hisaharu Kohzuki, Yutaka Kitagawa, Tamiji Nakashima, Akio Kikuta, and Miyako Takaki

O₂ consumption of mechanically unloaded contractions of mouse left ventricular myocardial slices
Am J Physiol Heart Circ Physiol 287: H54-H62, 2004. First published February 26, 2004; doi:10.1152/ajpheart.01082.2003 [Abstract] [Full Text] [PDF]  

Alfredo Sierra-Ramírez, Tomás Morato, Rafael Campos, Iván Rubio, Claudia Calzada, Enrique Méndez, and Guillermo Ceballos

Acute effects of testosterone on intracellular Ca²⁺ kinetics in rat coronary endothelial cells are exerted via aromatization to estrogens
Am J Physiol Heart Circ Physiol 287: H63-H71, 2004. First published January 15, 2004; doi:10.1152/ajpheart.00784.2003 [Abstract] [Full Text] [PDF]  

Peter M. Kang, Patrick Yue, Zhilin Liu, Oleg Tarnavski, Natalya Bodyak, and Seigo Izumo

Alterations in apoptosis regulatory factors during hypertrophy and heart failure
Am J Physiol Heart Circ Physiol 287: H72-H80, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00556.2003 [Abstract] [Full Text] [PDF]  

Masakuni Kido, Hajime Otani, Shiori Kyoi, Tomohiko Sumida, Hiroyoshi Fujiwara, Takayuki Okada, and Hiroji Imamura

Ischemic preconditioning-mediated restoration of membrane dystrophin during reperfusion correlates with protection against contraction-induced myocardial injury
Am J Physiol Heart Circ Physiol 287: H81-H90, 2004. First published March 4, 2004; doi:10.1152/ajpheart.01140.2003 [Abstract] [Full Text] [PDF]  

Bradley M. Palmer, David E. Fishbaugher, Joachim P. Schmitt, Yuan Wang, Norman R. Alpert, Christine E. Seidman, J. G. Seidman, Peter VanBuren, and David W. Maughan

Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium
Am J Physiol Heart Circ Physiol 287: H91-H99, 2004. First published March 4, 2004; doi:10.1152/ajpheart.01015.2003 [Abstract] [Full Text] [PDF]  

Nakako Kurimoto, Yong-Shan Nan, Zhi-Yong Chen, Guo-Gang Feng, Toru Komatsu, Nobuhisa Kandatsu, Junken Ko, Norio Kawai, and Naohisa Ishikawa

Effects of specific signal transduction inhibitors on increased permeability across rat endothelial monolayers induced by neuropeptide Y or VEGF
Am J Physiol Heart Circ Physiol 287: H100-H106, 2004. First published February 19, 2004; doi:10.1152/ajpheart.00922.2003 [Abstract] [Full Text] [PDF]  

Sagartirtha Sarkar, Elangovan Vellaichamy, David Young, and Subha Sen

Influence of cytokines and growth factors in ANG II-mediated collagen upregulation by fibroblasts in rats: role of myocytes
Am J Physiol Heart Circ Physiol 287: H107-H117, 2004. First published April 1, 2004; doi:10.1152/ajpheart.00763.2003 [Abstract] [Full Text] [PDF]  

Xi Wang, Emmanuelle Sentex, Donald Chapman, and Naranjan S. Dhalla

Alterations of adenylyl cyclase and G proteins in aortocaval shunt-induced heart failure
Am J Physiol Heart Circ Physiol 287: H118-H125, 2004. First published February 12, 2004; doi:10.1152/ajpheart.00798.2003 [Abstract] [Full Text] [PDF]  

Blair E. Cox, Timothy A. Roy, and Charles R. Rosenfeld

Angiotensin II mediates uterine vasoconstriction through -stimulation
Am J Physiol Heart Circ Physiol 287: H126-H134, 2004. First published February 19, 2004; doi:10.1152/ajpheart.00046.2003 [Abstract] [Full Text] [PDF]  

Tsuneo Kobayashi, Takayuki Matsumoto, Kazuyuki Ooishi, and Katsuo Kamata

Differential expression of _2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats
Am J Physiol Heart Circ Physiol 287: H135-H148, 2004. First published May 6, 2004; doi:10.1152/ajpheart.01074.2003 [Abstract] [Full Text] [PDF]  

John B. Buckwalter, Jason J. Hamann, Heidi A. Kluess, and Philip S. Clifford

Vasoconstriction in exercising skeletal muscles: a potential role for neuropeptide Y?
Am J Physiol Heart Circ Physiol 287: H144-H149, 2004; doi:10.1152/ajpheart.00071.2004 [Abstract] [Full Text] [PDF]  

Chunhua Cao, Chang Won Kang, Sung Zoo Kim, and Suhn Hee Kim

Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy
Am J Physiol Heart Circ Physiol 287: H150-H156, 2004. First published February 19, 2004; doi:10.1152/ajpheart.00977.2003 [Abstract] [Full Text] [PDF]  

Girija G. Konduri, Ivane Bakhutashvili, Recia Frenn, Indira Chandrasekhar, Elizabeth R. Jacobs, and Ashwani K. Khanna

P2Y purine receptor responses and expression in the pulmonary circulation of juvenile rabbits
Am J Physiol Heart Circ Physiol 287: H157-H164, 2004. First published February 12, 2004; doi:10.1152/ajpheart.00617.2003 [Abstract] [Full Text] [PDF]  

Yi Xu, Stephen J. Armstrong, Ivan A. Arenas, Daniel J. Pehowich, and Sandra T. Davidge

Cardioprotection by chronic estrogen or superoxide dismutase mimetic treatment in the aged female rat
Am J Physiol Heart Circ Physiol 287: H165-H171, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00037.2004 [Abstract] [Full Text] [PDF]  

David M. Roth, N. Chin Lai, Mei Hua Gao, Jeffery D. Drumm, Jesus Jimenez, James R. Feramisco, and H. Kirk Hammond

Indirect intracoronary delivery of adenovirus encoding adenylyl cyclase increases left ventricular contractile function in mice
Am J Physiol Heart Circ Physiol 287: H172-H177, 2004. First published March 4, 2004; doi:10.1152/ajpheart.01009.2003 [Abstract] [Full Text] [PDF]  

Yasushi Miyauchi, Michael C. Fishbein, and Hrayr S. Karagueuzian

Electrical current-induced atrial and pulmonary vein action potential duration shortening and repetitive activity
Am J Physiol Heart Circ Physiol 287: H178-H186, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00085.2004 [Abstract] [Full Text] [PDF]  

Jian-Xiong Chen, Ying Chen, Laura DeBusk, Wenyu Lin, and Pengnain Charles Lin

Dual functional roles of Tie-2/angiopoietin in TNF--mediated angiogenesis
Am J Physiol Heart Circ Physiol 287: H187-H195, 2004; doi:10.1152/ajpheart.01058.2003 [Abstract] [Full Text] [PDF]  

Satoshi Nishimura, So-ichiro Yasuda, Masayoshi Katoh, Kelly P. Yamada, Hiroshi Yamashita, Yasutake Saeki, Kenji Sunagawa, Ryozo Nagai, Toshiaki Hisada, and Seiryo Sugiura

Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions
Am J Physiol Heart Circ Physiol 287: H196-H202, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00948.2003 [Abstract] [Full Text] [PDF]  

Jens Titze, Mehdi Shakibaei, Markus Schafflhuber, Gundula Schulze-Tanzil, Markus Porst, Karl H. Schwind, Peter Dietsch, and Karl F. Hilgers

Glycosaminoglycan polymerization may enable osmotically inactive Na⁺ storage in the skin
Am J Physiol Heart Circ Physiol 287: H203-H208, 2004. First published February 19, 2004; doi:10.1152/ajpheart.01237.2003 [Abstract] [Full Text] [PDF]  

Bruno Levy, Chantal Vallée, Francois Lauzier, Gérard E. Plante, Arnaud Mansart, Jean-Pierre Mallie, and Olivier Lesur

Comparative effects of vasopressin, norepinephrine, and L-canavanine, a selective inhibitor of inducible nitric oxide synthase, in endotoxic shock
Am J Physiol Heart Circ Physiol 287: H209-H215, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00946.2003 [Abstract] [Full Text] [PDF]  

Yasuo Kansui, Koji Fujii, Keiichiro Nakamura, Kenichi Goto, Hideyuki Oniki, Isao Abe, Yosaburo Shibata, and Mitsuo Iida

Angiotensin II receptor blockade corrects altered expression of gap junctions in vascular endothelial cells from hypertensive rats
Am J Physiol Heart Circ Physiol 287: H216-H224, 2004. First published March 11, 2004; doi:10.1152/ajpheart.00915.2003 [Abstract] [Full Text] [PDF]  

Raquel Hernanz, Ana M. Briones, María J. Alonso, Elisabet Vila, and Mercedes Salaices

Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries
Am J Physiol Heart Circ Physiol 287: H225-H234, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00548.2003 [Abstract] [Full Text] [PDF]  

Antonio Crisafulli, Franco Melis, Filippo Tocco, Uberto M. Santoboni, Carlo Lai, Giovanni Angioy, Luigi Lorrai, Gianluigi Pittau, Alberto Concu, and Pasquale Pagliaro

Exercise-induced and nitroglycerin-induced myocardial preconditioning improves hemodynamics in patients with angina
Am J Physiol Heart Circ Physiol 287: H235-H242, 2004. First published March 11, 2004; doi:10.1152/ajpheart.00989.2003 [Abstract] [Full Text] [PDF]  

Marcus Carlsson, Peter Cain, Catarina Holmqvist, Freddy Stahlberg, Stig Lundback, and Hakan Arheden

Total heart volume variation throughout the cardiac cycle in humans
Am J Physiol Heart Circ Physiol 287: H243-H250, 2004. First published March 11, 2004; doi:10.1152/ajpheart.01125.2003 [Abstract] [Full Text] [PDF]  

Luis F. Joaquim, Vera M. Farah, Iveta Bernatova, Rubens Fazan, Jr., Robert Grubbs, and Mariana Morris

Enhanced heart rate variability and baroreflex index after stress and cholinesterase inhibition in mice
Am J Physiol Heart Circ Physiol 287: H251-H257, 2004. First published February 26, 2004; doi:10.1152/ajpheart.01136.2003 [Abstract] [Full Text] [PDF]  

Edward J. Lesnefsky, Qun Chen, Thomas J. Slabe, Maria S. K. Stoll, Paul E. Minkler, Medhat O. Hassan, Bernard Tandler, and Charles L. Hoppel

Ischemia, rather than reperfusion, inhibits respiration through cytochrome oxidase in the isolated, perfused rabbit heart: role of cardiolipin
Am J Physiol Heart Circ Physiol 287: H258-H267, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00348.2003 [Abstract] [Full Text] [PDF]  

Andrew N. Carr, Michael G. Davis, Elaine Eby-Wilkens, Brian W. Howard, Bryan A. Towne, Thomas E. Dufresne, and Kevin G. Peters

Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease
Am J Physiol Heart Circ Physiol 287: H268-H276, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00007.2004 [Abstract] [Full Text] [PDF]  

Yutaka Kitagawa, Daisuke Yamashita, Haruo Ito, and Miyako Takaki

Reversible effects of isoproterenol-induced hypertrophy on in situ left ventricular function in rat hearts
Am J Physiol Heart Circ Physiol 287: H277-H285, 2004. First published March 11, 2004; doi:10.1152/ajpheart.00073.2004 [Abstract] [Full Text] [PDF]  

Kunio Ohta, Takanori Nakajima, Alexander Y. L. Cheah, Syed H. E. Zaidi, Nilo Kaviani, Fayez Dawood, Xiao-Mang You, Peter Liu, Mansoor Husain, and Marlene Rabinovitch

Elafin-overexpressing mice have improved cardiac function after myocardial infarction
Am J Physiol Heart Circ Physiol 287: H286-H292, 2004. First published December 23, 2003; doi:10.1152/ajpheart.00479.2002 [Abstract] [Full Text] [PDF]  

Dhananjay K. Kaul, Xiao-du Liu, Stephana Choong, John D. Belcher, Gregory M. Vercellotti, and Robert P. Hebbel

Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice
Am J Physiol Heart Circ Physiol 287: H293-H301, 2004. First published March 4, 2004; doi:10.1152/ajpheart.01150.2003 [Abstract] [Full Text] [PDF]  

Craig L. Duvall, W. Robert Taylor, Daiana Weiss, and Robert E. Guldberg

Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury
Am J Physiol Heart Circ Physiol 287: H302-H310, 2004. First published March 11, 2004; doi:10.1152/ajpheart.00928.2003 [Abstract] [Full Text] [PDF] [Supplemental Movie]  

Yakhin Shimoni and Xiu-Fang Liu

Gender differences in ANG II levels and action on multiple K⁺ current modulation pathways in diabetic rats
Am J Physiol Heart Circ Physiol 287: H311-H319, 2004. First published April 15, 2004; doi:10.1152/ajpheart.01212.2003 [Abstract] [Full Text] [PDF]  

Pedro Cabrales, Amy G. Tsai, John A. Frangos, Juan C. Briceño, and Marcos Intaglietta

Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons
Am J Physiol Heart Circ Physiol 287: H320-H330, 2004; doi:10.1152/ajpheart.01166.2003 [Abstract] [Full Text] [PDF]  

H. L. Xu, H. M. Koenig, S. Ye, D. L. Feinstein, and D. A. Pelligrino

Influence of the glia limitans on pial arteriolar relaxation in the rat
Am J Physiol Heart Circ Physiol 287: H331-H339, 2004. First published February 12, 2004; doi:10.1152/ajpheart.00831.2003 [Abstract] [Full Text] [PDF]  

C. Berthonneche, T. Sulpice, F. Boucher, L. Gouraud, J. de Leiris, S. E. O'Connor, J.-M. Herbert, and P. Janiak

New insights into the pathological role of TNF- in early cardiac dysfunction and subsequent heart failure after infarction in rats
Am J Physiol Heart Circ Physiol 287: H340-H350, 2004; doi:10.1152/ajpheart.01210.2003 [Abstract] [Full Text] [PDF]  

Steven G. Lloyd, Peipei Wang, Huadong Zeng, and John C. Chatham

Impact of low-flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart
Am J Physiol Heart Circ Physiol 287: H351-H362, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00983.2003 [Abstract] [Full Text] [PDF]  

Pedro Cabrales, Amy G. Tsai, and Marcos Intaglietta

Microvascular pressure and functional capillary density in extreme hemodilution with low- and high-viscosity dextran and a low-viscosity Hb-based O₂ carrier
Am J Physiol Heart Circ Physiol 287: H363-H373, 2004. First published February 19, 2004; doi:10.1152/ajpheart.01039.2003 [Abstract] [Full Text] [PDF]  

Patricia C. E. de Groot, Fleur Poelkens, Miriam Kooijman, and Maria T. E. Hopman

Preserved flow-mediated dilation in the inactive legs of spinal cord-injured individuals
Am J Physiol Heart Circ Physiol 287: H374-H380, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00958.2003 [Abstract] [Full Text] [PDF]  

Jun-Tzu Chao, Gerald A. Meininger, Jan L. Patterson, Sarah A. L. Jones, Charles R. Partridge, Jessemy D. Neiger, E. Spencer Williams, Stephen J. Kaufman, Kenneth S. Ramos, and Emily Wilson

Regulation of ₇-integrin expression in vascular smooth muscle by injury-induced atherosclerosis
Am J Physiol Heart Circ Physiol 287: H381-H389, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00939.2003 [Abstract] [Full Text] [PDF]  

Steven C. Hao, David J. Christini, Kenneth M. Stein, Peter N. Jordan, Sei Iwai, Orville Bramwell, Steven M. Markowitz, Suneet Mittal, and Bruce B. Lerman

Effect of -adrenergic blockade on dynamic electrical restitution in vivo
Am J Physiol Heart Circ Physiol 287: H390-H394, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00749.2003 [Abstract] [Full Text] [PDF]  

Melinda M. Parnell, Jaye P. F. Chin-Dusting, Jennifer Starr, and David M. Kaye

In vivo and in vitro evidence for ACh-stimulated L-arginine uptake
Am J Physiol Heart Circ Physiol 287: H395-H400, 2004. First published March 11, 2004; doi:10.1152/ajpheart.01094.2003 [Abstract] [Full Text] [PDF]  

Lane M. Smith, R. Wayne Barbee, Kevin R. Ward, and Roland N. Pittman

Prolonged tissue PO₂ reduction after contraction in spinotrapezius muscle of spontaneously hypertensive rats
Am J Physiol Heart Circ Physiol 287: H401-H407, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00980.2002 [Abstract] [Full Text] [PDF]  

Veronica L. M. Rundell, David L. Geenen, Peter M. Buttrick, and Pieter P. de Tombe

Depressed cardiac tension cost in experimental diabetes is due to altered myosin heavy chain isoform expression
Am J Physiol Heart Circ Physiol 287: H408-H413, 2004. First published March 4, 2004; doi:10.1152/ajpheart.00049.2004 [Abstract] [Full Text] [PDF]  

Guy E. Alvarez, Tasha P. Ballard, Stacy D. Beske, and Kevin P. Davy

Subcutaneous obesity is not associated with sympathetic neural activation
Am J Physiol Heart Circ Physiol 287: H414-H418, 2004. First published February 26, 2004; doi:10.1152/ajpheart.01046.2003 [Abstract] [Full Text] [PDF]  

Magnus Bäck, Hong Qiu, Jesper Z. Haeggström, and Kiyoto Sakata

Leukotriene B₄ is an indirectly acting vasoconstrictor in guinea pig aorta via an inducible type of BLT receptor
Am J Physiol Heart Circ Physiol 287: H419-H424, 2004. First published March 11, 2004; doi:10.1152/ajpheart.00699.2003 [Abstract] [Full Text] [PDF]  

Graham R. Lee, David Bell, Elizabeth J. Kelso, Cymone C. H. Argent, and Barbara J. McDermott

Evidence for altered ET_B receptor characteristics during development and progression of ventricular cardiomyocyte hypertrophy
Am J Physiol Heart Circ Physiol 287: H425-H432, 2004. First published February 26, 2004; doi:10.1152/ajpheart.00461.2003 [Abstract] [Full Text] [PDF]  

CORRIGENDA:

CORRIGENDA
Am J Physiol Heart Circ Physiol 287: H433-H433, 2004; doi:10.1152/ajpheart.00246.2004 [Full Text] [PDF]  

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