EDITORIAL FOCUS:

Kim A. Dora

Editorial Focus  Does arterial myogenic tone determine blood flow distribution in vivo?
Am J Physiol Heart Circ Physiol 289: H1323-H1325, 2005; doi:10.1152/ajpheart.00513.2005 [Full Text] [PDF]  

ARTICLES:

Neela Kotecha and Michael A. Hill

Myogenic contraction in rat skeletal muscle arterioles: smooth muscle membrane potential and Ca²⁺ signaling
Am J Physiol Heart Circ Physiol 289: H1326-H1334, 2005. First published April 29, 2005; doi:10.1152/ajpheart.00323.2005 [Abstract] [Full Text] [PDF]  

Harish Vasudevan, Hong Xiang, and John H. McNeill

Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats
Am J Physiol Heart Circ Physiol 289: H1335-H1342, 2005. First published June 10, 2005; doi:10.1152/ajpheart.00399.2005 [Abstract] [Full Text] [PDF]  

Ashwani Malhotra, Rebecca Begley, Barinder P. S. Kang, Irmindra Rana, Jing Liu, Guiping Yang, Daria Mochly-Rosen, and Leonard G. Meggs

PKC--dependent survival signals in diabetic hearts
Am J Physiol Heart Circ Physiol 289: H1343-H1350, 2005. First published May 13, 2005; doi:10.1152/ajpheart.01200.2004 [Abstract] [Full Text] [PDF]  

Tony Karram, Anan Abbasi, Shlomo Keidar, Eliahu Golomb, Irit Hochberg, Joseph Winaver, Aaron Hoffman, and Zaid Abassi

Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure
Am J Physiol Heart Circ Physiol 289: H1351-H1358, 2005. First published May 13, 2005; doi:10.1152/ajpheart.01186.2004 [Abstract] [Full Text] [PDF]  

Helen Kiriazis, Xiao-Jun Du, Xinheng Feng, Elodie Hotchkin, Tanneale Marshall, Samara Finch, Xiao-Ming Gao, Gavin Lambert, Julia K. Choate, and David M. Kaye

Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation
Am J Physiol Heart Circ Physiol 289: H1359-H1365, 2005. First published May 13, 2005; doi:10.1152/ajpheart.01010.2004 [Abstract] [Full Text] [PDF]  

Zhengyuan Xia, Kuo-Hsing Kuo, David V. Godin, Michael J. Walker, Michelle C. Y. Tao, and David M. Ansley

15-F_2t-isoprostane exacerbates myocardial ischemia-reperfusion injury of isolated rat hearts
Am J Physiol Heart Circ Physiol 289: H1366-H1372, 2005. First published June 3, 2005; doi:10.1152/ajpheart.00042.2005 [Abstract] [Full Text] [PDF]  

Reshma S. Baliga, Alysia A. Chaves, Liang Jing, Leona W. Ayers, and John A. Bauer

AIDS-related vasculopathy: evidence for oxidative and inflammatory pathways in murine and human AIDS
Am J Physiol Heart Circ Physiol 289: H1373-H1380, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00304.2005 [Abstract] [Full Text] [PDF]  

Brett G. Zani and H. Glenn Bohlen

Transport of extracellular L-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production
Am J Physiol Heart Circ Physiol 289: H1381-H1390, 2005. First published April 22, 2005; doi:10.1152/ajpheart.01231.2004 [Abstract] [Full Text] [PDF]  

Sandrine Huez, Kathleen Retailleau, Philippe Unger, Adriana Pavelescu, Jean-Luc Vachiéry, Geneviève Derumeaux, and Robert Naeije

Right and left ventricular adaptation to hypoxia: a tissue Doppler imaging study
Am J Physiol Heart Circ Physiol 289: H1391-H1398, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00332.2005 [Abstract] [Full Text] [PDF]  

Caroline Ojaimi, Wei Li, Shintaro Kinugawa, Heiner Post, Anna Csiszar, Pal Pacher, Gabor Kaley, and Thomas H. Hintze

Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype
Am J Physiol Heart Circ Physiol 289: H1399-H1407, 2005. First published May 6, 2005; doi:10.1152/ajpheart.00170.2005 [Abstract] [Full Text] [PDF] [Supplemental Table]  

Andrew Fenning, Glenn Harrison, Roselyn Rose’meyer, Andrew Hoey, and Lindsay Brown

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats
Am J Physiol Heart Circ Physiol 289: H1408-H1416, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00140.2005 [Abstract] [Full Text] [PDF]  

Deepa Nagar, Xiao-tie Liu, and Charles R. Rosenfeld

Estrogen regulates ₁-subunit expression in Ca²⁺-activated K⁺ channels in arteries from reproductive tissues
Am J Physiol Heart Circ Physiol 289: H1417-H1427, 2005. First published May 27, 2005; doi:10.1152/ajpheart.01174.2004 [Abstract] [Full Text] [PDF]  

Steven Poelzing, Bradley J. Roth, and David S. Rosenbaum

Optical measurements reveal nature of intercellular coupling across ventricular wall
Am J Physiol Heart Circ Physiol 289: H1428-H1435, 2005. First published April 29, 2005; doi:10.1152/ajpheart.01245.2004 [Abstract] [Full Text] [PDF]  

Toshishige Shibamoto, Sen Cui, Zonghai Ruan, Wei Liu, Hiromichi Takano, and Yasutaka Kurata

Hepatic venoconstriction is involved in anaphylactic hypotension in rats
Am J Physiol Heart Circ Physiol 289: H1436-H1441, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00368.2005 [Abstract] [Full Text] [PDF]  

Charles W. Leffler, Liliya Balabanova, Alexander L. Fedinec, and Helena Parfenova

Nitric oxide increases carbon monoxide production by piglet cerebral microvessels
Am J Physiol Heart Circ Physiol 289: H1442-H1447, 2005. First published June 17, 2005; doi:10.1152/ajpheart.00464.2005 [Abstract] [Full Text] [PDF]  

Ying Hu, S. V. Penelope Jones, and Wolfgang H. Dillmann

Effects of hyperthyroidism on delayed rectifier K⁺ currents in left and right murine atria
Am J Physiol Heart Circ Physiol 289: H1448-H1455, 2005. First published May 13, 2005; doi:10.1152/ajpheart.00828.2004 [Abstract] [Full Text] [PDF]  

Samir Saba, Andrzej M. Janczewski, Linda C. Baker, Vladimir Shusterman, Erdal C. Gursoy, Arthur M. Feldman, Guy Salama, Charles F. McTiernan, and Barry London

Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-
Am J Physiol Heart Circ Physiol 289: H1456-H1467, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00733.2004 [Abstract] [Full Text] [PDF]  

Richard E. White, Guichun Han, Christiana Dimitropoulou, Shu Zhu, Katsuya Miyake, David Fulton, Shaylee Dave, and Scott A. Barman

Estrogen-induced contraction of coronary arteries is mediated by superoxide generated in vascular smooth muscle
Am J Physiol Heart Circ Physiol 289: H1468-H1475, 2005; doi:10.1152/ajpheart.01173.2004 [Abstract] [Full Text] [PDF]  

Syed R. Baber, Weiwen Deng, Jorge Rodriguez, Ryan G. Master, Trinity J. Bivalacqua, Albert L. Hyman, and Philip J. Kadowitz

Vasoactive prostanoids are generated from arachidonic acid by COX-1 and COX-2 in the mouse
Am J Physiol Heart Circ Physiol 289: H1476-H1487, 2005. First published April 29, 2005; doi:10.1152/ajpheart.00195.2005 [Abstract] [Full Text] [PDF]  

Adriana S. Torsoni, Talita M. Marin, Licio A. Velloso, and Kleber G. Franchini

RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes
Am J Physiol Heart Circ Physiol 289: H1488-H1496, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00692.2004 [Abstract] [Full Text] [PDF]  

Sebastian Grundmann, Imo Hoefer, Susann Ulusans, Niels van Royen, Stephan H. Schirmer, C. Keith Ozaki, Christoph Bode, Jan J. Piek, and Ivo Buschmann

Anti-tumor necrosis factor- therapies attenuate adaptive arteriogenesis in the rabbit
Am J Physiol Heart Circ Physiol 289: H1497-H1505, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00959.2004 [Abstract] [Full Text] [PDF]  

Sara Danzi, Peter Dubon, and Irwin Klein

Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation
Am J Physiol Heart Circ Physiol 289: H1506-H1511, 2005. First published May 13, 2005; doi:10.1152/ajpheart.00182.2005 [Abstract] [Full Text] [PDF]  

Jennifer G. Duncan, Rajashree Ravi, Linda B. Stull, and Anne M. Murphy

Chronic xanthine oxidase inhibition prevents myofibrillar protein oxidation and preserves cardiac function in a transgenic mouse model of cardiomyopathy
Am J Physiol Heart Circ Physiol 289: H1512-H1518, 2005. First published April 29, 2005; doi:10.1152/ajpheart.00168.2005 [Abstract] [Full Text] [PDF]  

Frédéric Jacob, Leah A. Clark, Pilar Ariza Guzman, and John W. Osborn

Role of renal nerves in development of hypertension in DOCA-salt model in rats: a telemetric approach
Am J Physiol Heart Circ Physiol 289: H1519-H1529, 2005. First published June 3, 2005; doi:10.1152/ajpheart.00206.2005 [Abstract] [Full Text] [PDF]  

David J. Durgan, Margaret A. Hotze, Tara M. Tomlin, Oluwaseun Egbejimi, Christophe Graveleau, E. Dale Abel, Chad A. Shaw, Molly S. Bray, Paul E. Hardin, and Martin E. Young

The intrinsic circadian clock within the cardiomyocyte
Am J Physiol Heart Circ Physiol 289: H1530-H1541, 2005. First published June 3, 2005; doi:10.1152/ajpheart.00406.2005 [Abstract] [Full Text] [PDF]  

Min Li and John N. Stallone

Estrogen potentiates vasopressin-induced contraction of female rat aorta by enhancing cyclooxygenase-2 and thromboxane function
Am J Physiol Heart Circ Physiol 289: H1542-H1550, 2005. First published June 3, 2005; doi:10.1152/ajpheart.01024.2004 [Abstract] [Full Text] [PDF]  

Eun A. Ko, Won Sun Park, Jae-Hong Ko, Jin Han, Nari Kim, and Yung E. Earm

Endothelin-1 increases intracellular Ca²⁺ in rabbit pulmonary artery smooth muscle cells through phospholipase C
Am J Physiol Heart Circ Physiol 289: H1551-H1559, 2005; doi:10.1152/ajpheart.00131.2005 [Abstract] [Full Text] [PDF]  

E. Ann Tallant, Carlos M. Ferrario, and Patricia E. Gallagher

Angiotensin-(1–7) inhibits growth of cardiac myocytes through activation of the mas receptor
Am J Physiol Heart Circ Physiol 289: H1560-H1566, 2005. First published June 10, 2005; doi:10.1152/ajpheart.00941.2004 [Abstract] [Full Text] [PDF]  

Sylvain Roy, Paolo Silacci, and Nikolaos Stergiopulos

Biomechanical proprieties of decellularized porcine common carotid arteries
Am J Physiol Heart Circ Physiol 289: H1567-H1576, 2005. First published May 20, 2005; doi:10.1152/ajpheart.00564.2004 [Abstract] [Full Text] [PDF]  

Ju-Feng Wang, Achim Meissner, Sohail Malek, Yu Chen, Qingen Ke, Jielin Zhang, Victor Chu, Thomas G. Hampton, Clyde S. Crumpacker, Walter H. Abelmann, Ivo Amende, and James P. Morgan

Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis
Am J Physiol Heart Circ Physiol 289: H1577-H1583, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00258.2005 [Abstract] [Full Text] [PDF]  

Richard Balasubramaniam, Sangeeta Chawla, Andrew A. Grace, and Christopher L.-H. Huang

Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca²⁺ homeostasis
Am J Physiol Heart Circ Physiol 289: H1584-H1593, 2005. First published May 27, 2005; doi:10.1152/ajpheart.01250.2004 [Abstract] [Full Text] [PDF]  

Alexander Omelchenko, Ron Bouchard, Sabin Shurraw, Michael Trac, Mark Hnatowich, and Larry V. Hryshko

Frequency-dependent regulation of cardiac Na⁺/Ca²⁺ exchanger
Am J Physiol Heart Circ Physiol 289: H1594-H1603, 2005. First published June 10, 2005; doi:10.1152/ajpheart.01094.2004 [Abstract] [Full Text] [PDF]  

Kenta Yamamoto, Toru Kawada, Atsunori Kamiya, Hiroshi Takaki, Masaru Sugimachi, and Kenji Sunagawa

Static interaction between muscle mechanoreflex and arterial baroreflex in determining efferent sympathetic nerve activity
Am J Physiol Heart Circ Physiol 289: H1604-H1609, 2005. First published May 20, 2005; doi:10.1152/ajpheart.00053.2005 [Abstract] [Full Text] [PDF]  

Brett S. Kirby, Rachel R. Markwald, Erica G. Smith, and Frank A. Dinenno

Mechanical effects of muscle contraction do not blunt sympathetic vasoconstriction in humans
Am J Physiol Heart Circ Physiol 289: H1610-H1617, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00391.2005 [Abstract] [Full Text] [PDF]  

Chad E. Darling, Rong Jiang, Michelle Maynard, Peter Whittaker, Jakob Vinten-Johansen, and Karin Przyklenk

Postconditioning via stuttering reperfusion limits myocardial infarct size in rabbit hearts: role of ERK1/2
Am J Physiol Heart Circ Physiol 289: H1618-H1626, 2005. First published June 3, 2005; doi:10.1152/ajpheart.00055.2005 [Abstract] [Full Text] [PDF]  

Ulrika Hägg, Birger Wandt, Göran Bergström, Reinhard Volkmann, and Li-ming Gan

Physical exercise capacity is associated with coronary and peripheral vascular function in healthy young adults
Am J Physiol Heart Circ Physiol 289: H1627-H1634, 2005. First published June 3, 2005; doi:10.1152/ajpheart.00135.2005 [Abstract] [Full Text] [PDF]  

Susumu Ohya, Yukiko Kuwata, Kazuho Sakamoto, Katsuhiko Muraki, and Yuji Imaizumi

Cardioprotective effects of estradiol include the activation of large-conductance Ca²⁺-activated K⁺ channels in cardiac mitochondria
Am J Physiol Heart Circ Physiol 289: H1635-H1642, 2005. First published August 19, 2005; doi:10.1152/ajpheart.00016.2005 [Abstract] [Full Text] [PDF]  

Xiang-Bin Xu, Jin-Jiang Pang, Ji-Min Cao, Chao Ni, Rong-Kun Xu, Xiao-Zhong Peng, Xiao-Xia Yu, Shu Guo, Meng-Chin Chen, and Chen Chen

GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure
Am J Physiol Heart Circ Physiol 289: H1643-H1651, 2005. First published June 10, 2005; doi:10.1152/ajpheart.01042.2004 [Abstract] [Full Text] [PDF]  

Antoine Younès, Salvatore Pepe, Darice Yoshishige, James L. Caffrey, and Edward G. Lakatta

Ischemic preconditioning increases the bioavailability of cardiac enkephalins
Am J Physiol Heart Circ Physiol 289: H1652-H1661, 2005; doi:10.1152/ajpheart.01110.2004 [Abstract] [Full Text] [PDF]  

C. A. Wauschkuhn, K. Witte, S. Gorbey, B. Lemmer, and L. Schilling

Circadian periodicity of cerebral blood flow revealed by laser-Doppler flowmetry in awake rats: relation to blood pressure and activity
Am J Physiol Heart Circ Physiol 289: H1662-H1668, 2005. First published May 13, 2005; doi:10.1152/ajpheart.01242.2004 [Abstract] [Full Text] [PDF]  

John P. Cullen, Shariq Sayeed, Ying Jin, Nicholas G. Theodorakis, James V. Sitzmann, Paul A. Cahill, and Eileen M. Redmond

Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1-activated human endothelial cells
Am J Physiol Heart Circ Physiol 289: H1669-H1675, 2005. First published May 20, 2005; doi:10.1152/ajpheart.00106.2005 [Abstract] [Full Text] [PDF]  

Nobuyuki Ono, Risuke Mizuno, and Toshio Ohhashi

Effective permeability of hydrophilic substances through walls of lymph vessels: roles of endothelial barrier
Am J Physiol Heart Circ Physiol 289: H1676-H1682, 2005. First published June 17, 2005; doi:10.1152/ajpheart.01084.2004 [Abstract] [Full Text] [PDF]  

Chanran K. Ganta, Ning Lu, Bryan G. Helwig, Frank Blecha, Roman R. Ganta, Ling Zheng, Christopher R. Ross, Timothy I. Musch, Richard J. Fels, and Michael J. Kenney

Central angiotensin II-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system
Am J Physiol Heart Circ Physiol 289: H1683-H1691, 2005. First published May 20, 2005; doi:10.1152/ajpheart.00125.2005 [Abstract] [Full Text] [PDF]  

Zhilin Qu and James N. Weiss

Effects of Na⁺ and K⁺ channel blockade on vulnerability to and termination of fibrillation in simulated normal cardiac tissue
Am J Physiol Heart Circ Physiol 289: H1692-H1701, 2005. First published June 3, 2005; doi:10.1152/ajpheart.00241.2005 [Abstract] [Full Text] [PDF]  

D. Konrad, A. Oldner, M. Wanecek, A. Rudehill, E. Weitzberg, B. Biber, G. Johansson, S. Häggmark, and M. Haney

Positive inotropic and negative lusitropic effects of endothelin receptor agonism in vivo
Am J Physiol Heart Circ Physiol 289: H1702-H1709, 2005. First published June 10, 2005; doi:10.1152/ajpheart.00892.2004 [Abstract] [Full Text] [PDF]  

F. M. Mo and H. J. Ballard

Acute systemic hypoxia elevates venous but not interstitial potassium of dog skeletal muscle
Am J Physiol Heart Circ Physiol 289: H1710-H1718, 2005. First published May 13, 2005; doi:10.1152/ajpheart.00614.2004 [Abstract] [Full Text] [PDF]  

Vladislav Ovchinnikov, Gen Suzuki, John M. Canty, Jr., and James A. Fallavollita

Blunted functional responses to pre- and postjunctional sympathetic stimulation in hibernating myocardium
Am J Physiol Heart Circ Physiol 289: H1719-H1728, 2005. First published May 27, 2005; doi:10.1152/ajpheart.00273.2005 [Abstract] [Full Text] [PDF]  

Sophie Motte, Myrielle Mathieu, Serge Brimioulle, Anne Pensis, Lynn Ray, Jean-Marie Ketelslegers, Nicola Montano, Robert Naeije, Philippe van de Borne, and Kathleen Mc Entee

Respiratory-related heart rate variability in progressive experimental heart failure
Am J Physiol Heart Circ Physiol 289: H1729-H1735, 2005. First published May 27, 2005; doi:10.1152/ajpheart.01129.2004 [Abstract] [Full Text] [PDF]  

Ravi Rajashree, Bradford C. Blunt, and Polly A. Hofmann

Modulation of myosin phosphatase targeting subunit and protein phosphatase 1 in the heart
Am J Physiol Heart Circ Physiol 289: H1736-H1743, 2005. First published May 20, 2005; doi:10.1152/ajpheart.00318.2004 [Abstract] [Full Text] [PDF]  

Shubha Varma, Brajesh K. Lal, Ruifang Zheng, Jerome W. Breslin, Satoshi Saito, Peter J. Pappas, Robert W. Hobson, II, and Walter N. Durán

Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction
Am J Physiol Heart Circ Physiol 289: H1744-H1751, 2005. First published June 17, 2005; doi:10.1152/ajpheart.01088.2004 [Abstract] [Full Text] [PDF]  

Friedrich Mittermayer, Johannes Pleiner, Georg Schaller, Stefan Zorn, Khodadad Namiranian, Stylianos Kapiotis, Gregor Bartel, Mathias Wolfrum, Mathias Brügel, Joachim Thiery, Raymond J. MacAllister, and Michael Wolzt

Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction
Am J Physiol Heart Circ Physiol 289: H1752-H1757, 2005. First published June 17, 2005; doi:10.1152/ajpheart.00057.2005 [Abstract] [Full Text] [PDF]  

Atsunori Kamiya, Junichiro Hayano, Toru Kawada, Daisaku Michikami, Kenta Yamamoto, Hideto Ariumi, Syuji Shimizu, Kazunori Uemura, Tadayoshi Miyamoto, Takeshi Aiba, Kenji Sunagawa, and Masaru Sugimachi

Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia
Am J Physiol Heart Circ Physiol 289: H1758-H1769, 2005. First published June 3, 2005; doi:10.1152/ajpheart.01027.2004 [Abstract] [Full Text] [PDF]  

Afsana Momen, Douglas Bower, Urs A. Leuenberger, John Boehmer, Susan Lerner, Edward J. Alfrey, Brian Handly, and Lawrence I. Sinoway

Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control
Am J Physiol Heart Circ Physiol 289: H1770-H1776, 2005. First published June 10, 2005; doi:10.1152/ajpheart.01213.2004 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Amy G. Tsai, Pedro Cabrales, Paul C. Johnson, Marcos Intaglietta, Aleksander S. Golub, and Roland N. Pittman

Effect of oxygen consumption by measuring method on PO₂ transients associated with the passage of erythrocytes in capillaries of rat mesentery
Am J Physiol Heart Circ Physiol 289: H1777-H1779, 2005; doi:10.1152/ajpheart.00503.2005 [Abstract] [Full Text] [PDF]  

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