EDITORIAL FOCUS:

Julian H. Lombard

Editorial Focus  A novel mechanism for regulation of retinal blood flow by lactate: gap junctions, hypoxia, and pericytes
Am J Physiol Heart Circ Physiol 290: H921-H922, 2006; doi:10.1152/ajpheart.01268.2005 [Full Text] [PDF]  

Joey P. Granger

Editorial Focus  An emerging role for inflammatory cytokines in hypertension
Am J Physiol Heart Circ Physiol 290: H923-H924, 2006; doi:10.1152/ajpheart.01278.2005 [Full Text] [PDF]  

ARTICLES:

Shigeki Yamanishi, Kozo Katsumura, Takatoshi Kobayashi, and Donald G. Puro

Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature
Am J Physiol Heart Circ Physiol 290: H925-H934, 2006. First published November 18, 2005; doi:10.1152/ajpheart.01012.2005 [Abstract] [Full Text] [PDF] [Supplemental Video]  

Dexter L. Lee, Lashon C. Sturgis, Hicham Labazi, James B. Osborne, Jr., Cassandra Fleming, Jennifer S. Pollock, Marlina Manhiani, John D. Imig, and Michael W. Brands

Angiotensin II hypertension is attenuated in interleukin-6 knockout mice
Am J Physiol Heart Circ Physiol 290: H935-H940, 2006. First published November 11, 2005; doi:10.1152/ajpheart.00708.2005 [Abstract] [Full Text] [PDF]  

Sangho Kim, Aleksander S. Popel, Marcos Intaglietta, and Paul C. Johnson

Effect of erythrocyte aggregation at normal human levels on functional capillary density in rat spinotrapezius muscle
Am J Physiol Heart Circ Physiol 290: H941-H947, 2006. First published September 23, 2005; doi:10.1152/ajpheart.00645.2005 [Abstract] [Full Text] [PDF]  

Claudie Hecquet, Dauren Biyashev, Fulong Tan, and Ervin G. Erdös

Positive cooperativity between the thrombin and bradykinin B₂ receptors enhances arachidonic acid release
Am J Physiol Heart Circ Physiol 290: H948-H958, 2006. First published September 23, 2005; doi:10.1152/ajpheart.00868.2005 [Abstract] [Full Text] [PDF]  

Ting-Ting Hong, Jinbao Huang, and Benedict R. Lucchesi

Effect of thrombolysis on myocardial injury: recombinant tissue plasminogen activator vs. alfimeprase
Am J Physiol Heart Circ Physiol 290: H959-H967, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00649.2005 [Abstract] [Full Text] [PDF]  

Xander A. A. M. Verbeek, Angelo Auricchio, Yinghong Yu, Jiang Ding, Thierry Pochet, Kevin Vernooy, Andrew Kramer, Julio Spinelli, and Frits W. Prinzen

Tailoring cardiac resynchronization therapy using interventricular asynchrony. Validation of a simple model
Am J Physiol Heart Circ Physiol 290: H968-H977, 2006. First published September 19, 2005; doi:10.1152/ajpheart.00641.2005 [Abstract] [Full Text] [PDF]  

Martin Rodriguez-Porcel, Xiang-Yang Zhu, Alejandro R. Chade, Beatriz Amores-Arriaga, Noel M. Caplice, Erik L. Ritman, Amir Lerman, and Lilach O. Lerman

Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension
Am J Physiol Heart Circ Physiol 290: H978-H984, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00538.2005 [Abstract] [Full Text] [PDF]  

Tuanzhu Ha, Fang Hua, Yuehua Li, Jing Ma, Xiang Gao, Jim Kelley, Aiqiu Zhao, Georges E. Haddad, David L. Williams, I. William Browder, Race L. Kao, and Chuanfu Li

Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo
Am J Physiol Heart Circ Physiol 290: H985-H994, 2006. First published September 30, 2005; doi:10.1152/ajpheart.00720.2005 [Abstract] [Full Text] [PDF]  

Chang-seng Liang, Weike Mao, Chikao Iwai, Shuji Fukuoka, and Suzanne Y. Stevens

Cardiac sympathetic neuroprotective effect of desipramine in tachycardia-induced cardiomyopathy
Am J Physiol Heart Circ Physiol 290: H995-H1003, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00569.2005 [Abstract] [Full Text] [PDF]  

Szilard Voros, Zequan Yang, Christina M. Bove, Wesley D. Gilson, Frederick H. Epstein, Brent A. French, Stuart S. Berr, Sanford P. Bishop, Mark R. Conaway, Hiroaki Matsubara, Robert M. Carey, and Christopher M. Kramer

Interaction between AT₁ and AT₂ receptors during postinfarction left ventricular remodeling
Am J Physiol Heart Circ Physiol 290: H1004-H1010, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00886.2005 [Abstract] [Full Text] [PDF]  

Lisa M. Schwartz and Claudia J. Lagranha

Ischemic postconditioning during reperfusion activates Akt and ERK without protecting against lethal myocardial ischemia-reperfusion injury in pigs
Am J Physiol Heart Circ Physiol 290: H1011-H1018, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00864.2005 [Abstract] [Full Text] [PDF]  

Xiaoling Dai, Xian Cao, and David L. Kreulen

Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase
Am J Physiol Heart Circ Physiol 290: H1019-H1026, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00052.2005 [Abstract] [Full Text] [PDF]  

Annette Rebel, Suyi Cao, Herman Kwansa, Sylvain Doré, Enrico Bucci, and Raymond C. Koehler

Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin
Am J Physiol Heart Circ Physiol 290: H1027-H1037, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00500.2005 [Abstract] [Full Text] [PDF]  

Shetuan Zhang

Isolation and characterization of I_Kr in cardiac myocytes by Cs⁺ permeation
Am J Physiol Heart Circ Physiol 290: H1038-H1049, 2006. First published October 14, 2005; doi:10.1152/ajpheart.00679.2005 [Abstract] [Full Text] [PDF]  

János Szebeni, Lajos Baranyi, Sándor Sávay, Michael Bodó, János Milosevits, Carl R. Alving, and Rolf Bünger

Complement activation-related cardiac anaphylaxis in pigs: role of C5a anaphylatoxin and adenosine in liposome-induced abnormalities in ECG and heart function
Am J Physiol Heart Circ Physiol 290: H1050-H1058, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00622.2005 [Abstract] [Full Text] [PDF]  

Maria Cristina O. Salgado, Soraia V. S. Justo, Luis F. Joaquim, Rubens Fazan, Jr., and Helio C. Salgado

Role of nitric oxide and prostanoids in attenuation of rapid baroreceptor resetting
Am J Physiol Heart Circ Physiol 290: H1059-H1063, 2006. First published October 14, 2005; doi:10.1152/ajpheart.00219.2005 [Abstract] [Full Text] [PDF]  

Shinsuke Kido, Naoyuki Hasebe, Yoshinao Ishii, and Kenjiro Kikuchi

Tachycardia-induced myocardial ischemia and diastolic dysfunction potentiate secretion of ANP, not BNP, in hypertrophic cardiomyopathy
Am J Physiol Heart Circ Physiol 290: H1064-H1070, 2006. First published September 19, 2005; doi:10.1152/ajpheart.00110.2005 [Abstract] [Full Text] [PDF]  

Murat Ayaz and Belma Turan

Selenium prevents diabetes-induced alterations in [Zn²⁺]_i and metallothionein level of rat heart via restoration of cell redox cycle
Am J Physiol Heart Circ Physiol 290: H1071-H1080, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00754.2005 [Abstract] [Full Text] [PDF]  

Jamila Ibrahim, Ann McGee, Delyth Graham, John C. McGrath, and Anna F. Dominiczak

Sex-specific differences in cerebral arterial myogenic tone in hypertensive and normotensive rats
Am J Physiol Heart Circ Physiol 290: H1081-H1089, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00752.2005 [Abstract] [Full Text] [PDF]  

Steven E. Anderson, Hong Liu, Andrea Beyschau, and Peter M. Cala

Effects of cold cardioplegia on pH, Na, and Ca in newborn rabbit hearts
Am J Physiol Heart Circ Physiol 290: H1090-H1097, 2006. First published October 14, 2005; doi:10.1152/ajpheart.00776.2004 [Abstract] [Full Text] [PDF]  

Xiaoming Yi, Raffi Bekeredjian, Nicholas J. DeFilippis, Zakir Siddiquee, Eduardo Fernandez, and Ralph V. Shohet

Transcriptional analysis of doxorubicin-induced cardiotoxicity
Am J Physiol Heart Circ Physiol 290: H1098-H1102, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00832.2005 [Abstract] [Full Text] [PDF]  

Lynne Turnbull, Hui-Zhong Zhou, Philip M. Swigart, Sally Turcato, Joel S. Karliner, Bruce R. Conklin, Paul C. Simpson, and Anthony J. Baker

Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator
Am J Physiol Heart Circ Physiol 290: H1103-H1109, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00732.2005 [Abstract] [Full Text] [PDF]  

De-Pei Li and Hui-Lin Pan

Plasticity of GABAergic control of hypothalamic presympathetic neurons in hypertension
Am J Physiol Heart Circ Physiol 290: H1110-H1119, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00788.2005 [Abstract] [Full Text] [PDF]  

Yoshihide Fujisawa, Yukiko Nagai, Akira Miyatake, Katsuyuki Miura, Takatomi Shokoji, Akira Nishiyama, Shoji Kimura, and Youichi Abe

Roles of adrenomedullin 2 in regulating the cardiovascular and sympathetic nervous systems in conscious rats
Am J Physiol Heart Circ Physiol 290: H1120-H1127, 2006. First published October 14, 2005; doi:10.1152/ajpheart.00461.2005 [Abstract] [Full Text] [PDF]  

Cristine L. Heaps, Mildred L. Mattox, Katherine A. Kelly, Cynthia J. Meininger, and Janet L. Parker

Exercise training increases basal tone in arterioles distal to chronic coronary occlusion
Am J Physiol Heart Circ Physiol 290: H1128-H1135, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00973.2005 [Abstract] [Full Text] [PDF]  

Xiu-Yu Yi, Victoria X. Li, Fan Zhang, Fan Yi, Daniel R. Matson, Ming Tao Jiang, and Pin-Lan Li

Characteristics and actions of NAD(P)H oxidase on the sarcoplasmic reticulum of coronary artery smooth muscle
Am J Physiol Heart Circ Physiol 290: H1136-H1144, 2006. First published October 14, 2005; doi:10.1152/ajpheart.00296.2005 [Abstract] [Full Text] [PDF]  

F. M. Lynch, C. Austin, A. M. Heagerty, and A. S. Izzard

Adenosine and hypoxic dilation of rat coronary small arteries: roles of the ATP-sensitive potassium channel, endothelium, and nitric oxide
Am J Physiol Heart Circ Physiol 290: H1145-H1150, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00314.2005 [Abstract] [Full Text] [PDF]  

May Azzawi and Clare Austin

Extravascular pressure modulates responses of isolated rat coronary arteries to vasodilator, but not vasoconstrictor, stimuli
Am J Physiol Heart Circ Physiol 290: H1151-H1156, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00307.2005 [Abstract] [Full Text] [PDF]  

Galia K. Soukhova-O'Hare, Zixi (Jack) Cheng, Andrew M. Roberts, and David Gozal

Postnatal intermittent hypoxia alters baroreflex function in adult rats
Am J Physiol Heart Circ Physiol 290: H1157-H1164, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00767.2005 [Abstract] [Full Text] [PDF]  

Jacob Tfelt-Hansen, Jakob Lerche Hansen, Sanela Smajilovic, Ernest F. Terwilliger, Stig Haunso, and Soren P. Sheikh

Calcium receptor is functionally expressed in rat neonatal ventricular cardiomyocytes
Am J Physiol Heart Circ Physiol 290: H1165-H1171, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00821.2005 [Abstract] [Full Text] [PDF]  

Guo Zhang, Eric G. Teggatz, Andrew Y. Zhang, Matthew J. Koeberl, Fan Yi, Li Chen, and Pin-Lan Li

Cyclic ADP ribose-mediated Ca²⁺ signaling in mediating endothelial nitric oxide production in bovine coronary arteries
Am J Physiol Heart Circ Physiol 290: H1172-H1181, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00441.2005 [Abstract] [Full Text] [PDF]  

Barbara E. Stähli, Helen Greutert, Shaoping Mei, Philipp Graf, Karin Frischknecht, Mario Stalder, Lars Englberger, Andreas Künzli, Leo Schärer, Thomas F. Lüscher, Thierry P. Carrel, and Felix C. Tanner

Absence of histamine-induced nitric oxide release in the human radial artery: implications for vasospasm of coronary artery bypass vessels
Am J Physiol Heart Circ Physiol 290: H1182-H1189, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00280.2005 [Abstract] [Full Text] [PDF]  

Richard M. Fitch, John C. Rutledge, Yi-Xin Wang, Andrew F. Powers, Jih-Lie Tseng, Taegan Clary, and Gabor M. Rubanyi

Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice
Am J Physiol Heart Circ Physiol 290: H1190-H1198, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00327.2005 [Abstract] [Full Text] [PDF]  

Brant E. Isakson, David N. Damon, Kathleen H. Day, Yongbo Liao, and Brian R. Duling

Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation
Am J Physiol Heart Circ Physiol 290: H1199-H1205, 2006. First published November 11, 2005; doi:10.1152/ajpheart.00945.2005 [Abstract] [Full Text] [PDF]  

David Lominadze, Andrew M. Roberts, Neetu Tyagi, Karni S. Moshal, and Suresh C. Tyagi

Homocysteine causes cerebrovascular leakage in mice
Am J Physiol Heart Circ Physiol 290: H1206-H1213, 2006. First published October 28, 2005; doi:10.1152/ajpheart.00376.2005 [Abstract] [Full Text] [PDF]  

Angela E. Kindig, Shawn G. Hayes, Ramy L. Hanna, and Marc P. Kaufman

P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch
Am J Physiol Heart Circ Physiol 290: H1214-H1219, 2006. First published October 28, 2005; doi:10.1152/ajpheart.01051.2005 [Abstract] [Full Text] [PDF]  

Deborah H. Damon

Vascular endothelial-derived semaphorin 3 inhibits sympathetic axon growth
Am J Physiol Heart Circ Physiol 290: H1220-H1225, 2006. First published October 28, 2005; doi:10.1152/ajpheart.01232.2004 [Abstract] [Full Text] [PDF]  

Robert Parent, Normand Leblanc, and Michel Lavallée

Nitroglycerin reduces myocardial oxygen consumption during exercise despite vascular tolerance
Am J Physiol Heart Circ Physiol 290: H1226-H1234, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00607.2005 [Abstract] [Full Text] [PDF]  

Li Zhang, Markus Frederich, Huamei He, and James A. Balschi

Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart
Am J Physiol Heart Circ Physiol 290: H1235-H1243, 2006. First published October 28, 2005; doi:10.1152/ajpheart.00906.2005 [Abstract] [Full Text] [PDF]  

Dauren Biyashev, Fulong Tan, Zhenlong Chen, Kai Zhang, Peter A. Deddish, Ervin G. Erdös, and Claudie Hecquet

Kallikrein activates bradykinin B₂ receptors in absence of kininogen
Am J Physiol Heart Circ Physiol 290: H1244-H1250, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00934.2005 [Abstract] [Full Text] [PDF]  

Gerard D’Angelo, Jennifer S. Pollock, and David M. Pollock

In vivo evidence for endothelin-1-mediated attenuation of ₁-adrenergic stimulation
Am J Physiol Heart Circ Physiol 290: H1251-H1258, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00203.2005 [Abstract] [Full Text] [PDF]  

Ivan A. Arenas, Yi Xu, and Sandra T. Davidge

Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF- antagonism
Am J Physiol Heart Circ Physiol 290: H1259-H1263, 2006. First published November 11, 2005; doi:10.1152/ajpheart.00990.2005 [Abstract] [Full Text] [PDF]  

Benedek Erdös, James A. Snipes, Christina D. Tulbert, Prasad Katakam, Allison W. Miller, and David W. Busija

Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production
Am J Physiol Heart Circ Physiol 290: H1264-H1270, 2006. First published November 11, 2005; doi:10.1152/ajpheart.00804.2005 [Abstract] [Full Text] [PDF]  

D. Walter Wray, Abhimanyu Uberoi, Lesley Lawrenson, and Russell S. Richardson

Evidence of preserved endothelial function and vascular plasticity with age
Am J Physiol Heart Circ Physiol 290: H1271-H1277, 2006. First published November 4, 2005; doi:10.1152/ajpheart.00883.2005 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY:

Sridharan Rajamani, Corey L. Anderson, Carmen R. Valdivia, Lee L. Eckhardt, Jason D. Foell, Gail A. Robertson, Timothy J. Kamp, Jonathan C. Makielski, Blake D. Anson, and Craig T. January

Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I_Kr
Am J Physiol Heart Circ Physiol 290: H1278-H1288, 2006. First published October 14, 2005; doi:10.1152/ajpheart.00777.2005 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

A. Nemes, Tamás Forster, and Miklós Csanády

Relationship between coronary flow velocity reserve and aortic stiffness
Am J Physiol Heart Circ Physiol 290: H1311-H1311, 2006; doi:10.1152/ajpheart.01187.2005 [Abstract] [Full Text] [PDF]  

REPORTS:

Vernat J. Exil, Carla D. Gardner, Jeffrey N. Rottman, Harold Sims, Beatrijs Bartelds, Zaza Khuchua, Rekha Sindhal, Gemin Ni, and Arnold W. Strauss

Abnormal mitochondrial bioenergetics and heart rate dysfunction in mice lacking very-long-chain acyl-CoA dehydrogenase
Am J Physiol Heart Circ Physiol 290: H1289-H1297, 2006. First published September 30, 2005; doi:10.1152/ajpheart.00811.2005 [Abstract] [Full Text] [PDF]  

William R. Mills, Niladri Mal, Farhad Forudi, Zoran B. Popovic, Marc S. Penn, and Kenneth R. Laurita

Optical mapping of late myocardial infarction in rats
Am J Physiol Heart Circ Physiol 290: H1298-H1306, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00437.2005 [Abstract] [Full Text] [PDF]  

Jürgen R. Sindermann, Christiane Köbbert, Adriane Skaletz-Rorowski, Günter Breithardt, Gabriele Plenz, and Keith L. March

Vascular injury response in mice is dependent on genetic background
Am J Physiol Heart Circ Physiol 290: H1307-H1310, 2006. First published October 7, 2005; doi:10.1152/ajpheart.00196.2005 [Abstract] [Full Text] [PDF]  

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