CALL FOR PAPERS:

Jian-Yong Qian, Alicia Leung, Pamela Harding, and Margot C. LaPointe

PGE₂ stimulates human brain natriuretic peptide expression via EP₄ and p42/44 MAPK
Am J Physiol Heart Circ Physiol 290: H1740-H1746, 2006. First published January 20, 2006; doi:10.1152/ajpheart.00904.2005 [Abstract] [Full Text] [PDF]  

INVITED REVIEW:

Jun Chen and Michael S. Goligorsky

Premature senescence of endothelial cells: Methusaleh's dilemma
Am J Physiol Heart Circ Physiol 290: H1729-H1739, 2006; doi:10.1152/ajpheart.01103.2005 [Abstract] [Full Text] [PDF]  

EDITORIAL FOCUS:

Heiner Post and Burkert Pieske

Editorial Focus  Arginase: a modulator of myocardial function
Am J Physiol Heart Circ Physiol 290: H1747-H1748, 2006. First published January 20, 2006; doi:10.1152/ajpheart.00056.2006 [Full Text] [PDF]  

Patrick H. McNulty

Editorial Focus  Metabolic responsiveness to insulin in the diabetic heart
Am J Physiol Heart Circ Physiol 290: H1749-H1751, 2006; doi:10.1152/ajpheart.00037.2006 [Full Text] [PDF]  

Gary J. Grover

Editorial Focus  Mitochondrial ATP-sensitive potassium channels and mitochondrial protein kinase C: sometimes it's good to have a close neighbor
Am J Physiol Heart Circ Physiol 290: H1752-H1753, 2006; doi:10.1152/ajpheart.00015.2006 [Full Text] [PDF]  

Michael P. Murphy

Editorial Focus  Induction of mitochondrial ROS production by electrophilic lipids: a new pathway of redox signaling?
Am J Physiol Heart Circ Physiol 290: H1754-H1755, 2006. First published January 13, 2006; doi:10.1152/ajpheart.00040.2006 [Full Text] [PDF]  

ARTICLES:

Albert S. Jung, Hajime Kubo, Rachel Wilson, Steven R. Houser, and Kenneth B. Margulies

Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium
Am J Physiol Heart Circ Physiol 290: H1756-H1762, 2006. First published December 3, 2005; doi:10.1152/ajpheart.01104.2005 [Abstract] [Full Text] [PDF]  

Anne Dragøy Hafstad, Geir Helge Solevåg, David L. Severson, Terje S. Larsen, and Ellen Aasum

Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin
Am J Physiol Heart Circ Physiol 290: H1763-H1769, 2006. First published December 3, 2005; doi:10.1152/ajpheart.01063.2005 [Abstract] [Full Text] [PDF]  

Ming Tao Jiang, Marko Ljubkovic, Yuri Nakae, Yang Shi, Wai-Meng Kwok, David F. Stowe, and Zeljko J. Bosnjak

Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro
Am J Physiol Heart Circ Physiol 290: H1770-H1776, 2006. First published December 16, 2005; doi:10.1152/ajpheart.01084.2005 [Abstract] [Full Text] [PDF]  

Aimee Landar, Jaroslaw W. Zmijewski, Dale A. Dickinson, Claire Le Goffe, Michelle S. Johnson, Ginger L. Milne, Giuseppe Zanoni, Giovanni Vidari, Jason D. Morrow, and Victor M. Darley-Usmar

Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species
Am J Physiol Heart Circ Physiol 290: H1777-H1787, 2006. First published December 30, 2005; doi:10.1152/ajpheart.01087.2005 [Abstract] [Full Text] [PDF]  

Xiaomei Guo, Xiao Lu, Huimin Ren, Ellis R. Levin, and Ghassan S. Kassab

Estrogen modulates the mechanical homeostasis of mouse arterial vessels through nitric oxide
Am J Physiol Heart Circ Physiol 290: H1788-H1797, 2006. First published November 23, 2005; doi:10.1152/ajpheart.01070.2005 [Abstract] [Full Text] [PDF]  

Ya Xu, Li Lu, Clifford Greyson, Mona Rizeq, Karin Nunley, Beata Wyatt, Michael R. Bristow, Carlin S. Long, and Gregory G. Schwartz

The PPAR- activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs
Am J Physiol Heart Circ Physiol 290: H1798-H1807, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00631.2005 [Abstract] [Full Text] [PDF]  

Dang Van Cuong, Nari Kim, Jae Boum Youm, Hyun Joo, Mohamad Warda, Jae-Wha Lee, Won Sun Park, Taeho Kim, Sunghyun Kang, Hyungkyu Kim, and Jin Han

Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K⁺ channels in rat hearts
Am J Physiol Heart Circ Physiol 290: H1808-H1817, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00772.2005 [Abstract] [Full Text] [PDF]  

Lisa M. Smyth, Leanne T. Breen, and Violeta N. Mutafova-Yambolieva

Nicotinamide adenine dinucleotide is released from sympathetic nerve terminals via a botulinum neurotoxin A-mediated mechanism in canine mesenteric artery
Am J Physiol Heart Circ Physiol 290: H1818-H1825, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01062.2005 [Abstract] [Full Text] [PDF]  

Ryuji Hataishi, Warren M. Zapol, Kenneth D. Bloch, and Fumito Ichinose

Inhaled nitric oxide does not reduce systemic vascular resistance in mice
Am J Physiol Heart Circ Physiol 290: H1826-H1829, 2006. First published November 18, 2005; doi:10.1152/ajpheart.00938.2005 [Abstract] [Full Text] [PDF]  

Ramakrishna Mukkamala, Jong-Kyung Kim, Ying Li, Javier Sala-Mercado, Robert L. Hammond, Tadeusz J. Scislo, and Donal S. O'Leary

Estimation of arterial and cardiopulmonary total peripheral resistance baroreflex gain values: validation by chronic arterial baroreceptor denervation
Am J Physiol Heart Circ Physiol 290: H1830-H1836, 2006. First published November 23, 2005; doi:10.1152/ajpheart.00898.2005 [Abstract] [Full Text] [PDF]  

Cenk Ayata and Michael A. Moskowitz

Cortical spreading depression confounds concentration-dependent pial arteriolar dilation during N-methyl-D-aspartate superfusion
Am J Physiol Heart Circ Physiol 290: H1837-H1841, 2006. First published November 18, 2005; doi:10.1152/ajpheart.01102.2005 [Abstract] [Full Text] [PDF]  

Shivani Mittra and Jean-Pierre Bourreau

G_s and G_i coupling of adrenomedullin in adult rat ventricular myocytes
Am J Physiol Heart Circ Physiol 290: H1842-H1847, 2006. First published December 3, 2005; doi:10.1152/ajpheart.00388.2005 [Abstract] [Full Text] [PDF]  

Steven J. Prior, James M. Hagberg, Chad M. Paton, Larry W. Douglass, Michael D. Brown, John C. McLenithan, and Stephen M. Roth

DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption
Am J Physiol Heart Circ Physiol 290: H1848-H1855, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01033.2005 [Abstract] [Full Text] [PDF]  

T. K. Bergersen, T. W. Hartgill, and J. Pirhonen

Cerebrovascular response to normal pregnancy: a longitudinal study
Am J Physiol Heart Circ Physiol 290: H1856-H1861, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00919.2005 [Abstract] [Full Text] [PDF]  

Xi-Lin Chen, Geraldine Dodd, Suzanne Thomas, Xiaolan Zhang, Martin A. Wasserman, Brad H. Rovin, and Charles Kunsch

Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
Am J Physiol Heart Circ Physiol 290: H1862-H1870, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00651.2005 [Abstract] [Full Text] [PDF]  

Devinder Rehal, Xiaomei Guo, Xiao Lu, and Ghassan S. Kassab

Duration of no-load state affects opening angle of porcine coronary arteries
Am J Physiol Heart Circ Physiol 290: H1871-H1878, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00910.2005 [Abstract] [Full Text] [PDF]  

Yakhin Shimoni, Don Hunt, Keyun Chen, Teresa Emmett, and Gary Kargacin

Differential autocrine modulation of atrial and ventricular potassium currents and of oxidative stress in diabetic rats
Am J Physiol Heart Circ Physiol 290: H1879-H1888, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01045.2005 [Abstract] [Full Text] [PDF]  

Tadeusz J. Scislo and Donal S. O'Leary

Vasopressin V₁ receptors contribute to hemodynamic and sympathoinhibitory responses evoked by stimulation of adenosine A_2a receptors in NTS
Am J Physiol Heart Circ Physiol 290: H1889-H1898, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01030.2005 [Abstract] [Full Text] [PDF]  

Eric E. Morgan, Julie H. Rennison, Martin E. Young, Tracy A. McElfresh, Theodore A. Kung, Kou-Yi Tserng, Brian D. Hoit, William C. Stanley, and Margaret P. Chandler

Effects of chronic activation of peroxisome proliferator-activated receptor- or high-fat feeding in a rat infarct model of heart failure
Am J Physiol Heart Circ Physiol 290: H1899-H1904, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01014.2005 [Abstract] [Full Text] [PDF]  

Shintaro Yamamoto and Tsuguhisa Ehara

Acidic extracellular pH-activated outwardly rectifying chloride current in mammalian cardiac myocytes
Am J Physiol Heart Circ Physiol 290: H1905-H1914, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00965.2005 [Abstract] [Full Text] [PDF]  

Xuesong Chen, Kristin Pavlish, Hai-Ying Zhang, and Joseph N. Benoit

Effects of chronic portal hypertension on agonist-induced actin polymerization in small mesenteric arteries
Am J Physiol Heart Circ Physiol 290: H1915-H1921, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00643.2005 [Abstract] [Full Text] [PDF]  

Peter Oishi, Anthony Azakie, Cynthia Harmon, Robert K. Fitzgerald, Albert Grobe, Jie Xu, Karen Hendricks-Munoz, Stephen M. Black, and Jeffrey R. Fineman

Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs
Am J Physiol Heart Circ Physiol 290: H1922-H1932, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01091.2005 [Abstract] [Full Text] [PDF]  

Mitchell Weaver, Jianhua Liu, David Pimentel, Daniel J. Reddy, Pamela Harding, Edward L. Peterson, and Patrick J. Pagano

Adventitial delivery of dominant-negative p67^phox attenuates neointimal hyperplasia of the rat carotid artery
Am J Physiol Heart Circ Physiol 290: H1933-H1941, 2006; doi:10.1152/ajpheart.00690.2005 [Abstract] [Full Text] [PDF]  

Joanna K. Davies, Dominic J. Wells, Ke Liu, Helen R. Whitrow, Tyrone D. Daniel, Robert Grignani, Craig A. Lygate, Jürgen E. Schneider, Gaëtane Noël, Hugh Watkins, and David Carling

Characterization of the role of 2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome
Am J Physiol Heart Circ Physiol 290: H1942-H1951, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01020.2005 [Abstract] [Full Text] [PDF]  

Maxime Cannesson, Didier Jacques, Michael R. Pinsky, and John Gorcsan, III

Effects of modulation of left ventricular contractile state and loading conditions on tissue Doppler myocardial performance index
Am J Physiol Heart Circ Physiol 290: H1952-H1959, 2006. First published December 16, 2005; doi:10.1152/ajpheart.01090.2005 [Abstract] [Full Text] [PDF]  

Shaul Atar, Yumei Ye, Yu Lin, Sheldon Y. Freeberg, Shawn P. Nishi, Salvatore Rosanio, Ming-He Huang, Barry F. Uretsky, Jose R. Perez-Polo, and Yochai Birnbaum

Atorvastatin-induced cardioprotection is mediated by increasing inducible nitric oxide synthase and consequent S-nitrosylation of cyclooxygenase-2
Am J Physiol Heart Circ Physiol 290: H1960-H1968, 2006. First published December 9, 2005; doi:10.1152/ajpheart.01137.2005 [Abstract] [Full Text] [PDF]  

Maria Natalia Cruz, Leonid Luksha, Henareh Logman, Lucilla Poston, Stefan Agewall, and Karolina Kublickiene

Acute responses to phytoestrogens in small arteries from men with coronary heart disease
Am J Physiol Heart Circ Physiol 290: H1969-H1975, 2006. First published December 16, 2005; doi:10.1152/ajpheart.01065.2005 [Abstract] [Full Text] [PDF]  

Andrew E. Pollard and Roger C. Barr

Cardiac microimpedance measurement in two-dimensional models using multisite interstitial stimulation
Am J Physiol Heart Circ Physiol 290: H1976-H1987, 2006. First published December 22, 2005; doi:10.1152/ajpheart.01180.2005 [Abstract] [Full Text] [PDF]  

William P. Robinson, III, Christelle D. Douillet, Peter M. Milano, Richard C. Boucher, Cam Patterson, and Preston B. Rich

ATP stimulates MMP-2 release from human aortic smooth muscle cells via JNK signaling pathway
Am J Physiol Heart Circ Physiol 290: H1988-H1996, 2006. First published December 16, 2005; doi:10.1152/ajpheart.00344.2005 [Abstract] [Full Text] [PDF]  

Fan Xiang, Yasuhiko Sakata, Lei Cui, Joey M. Youngblood, Hironori Nakagami, James K. Liao, Ronglih Liao, and Michael T. Chin

Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4
Am J Physiol Heart Circ Physiol 290: H1997-H2006, 2006; doi:10.1152/ajpheart.01106.2005 [Abstract] [Full Text] [PDF]  

Joseph Winaver, Elena Ovcharenko, Irit Rubinstein, Konstantin Gurbanov, Piero Pollesello, Bishara Bishara, Aaron Hoffman, and Zaid Abassi

Involvement of Rho kinase pathway in the mechanism of renal vasoconstriction and cardiac hypertrophy in rats with experimental heart failure
Am J Physiol Heart Circ Physiol 290: H2007-H2014, 2006. First published December 16, 2005; doi:10.1152/ajpheart.00600.2005 [Abstract] [Full Text] [PDF]  

Eno Essien Ebong, Sanghee Kim, and Natacha DePaola

Flow regulates intercellular communication in HAEC by assembling functional Cx40 and Cx37 gap junctional channels
Am J Physiol Heart Circ Physiol 290: H2015-H2023, 2006. First published December 16, 2005; doi:10.1152/ajpheart.00204.2005 [Abstract] [Full Text] [PDF]  

Jae-Sung Kim, Yingai Jin, and John J. Lemasters

Reactive oxygen species, but not Ca²⁺ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion
Am J Physiol Heart Circ Physiol 290: H2024-H2034, 2006. First published January 6, 2006; doi:10.1152/ajpheart.00683.2005 [Abstract] [Full Text] [PDF]  

Vera Gonscherowski, Bernhard F. Becker, Louis Moroder, Elena Motrescu, Shirley Gil-Parrado, Torsten Gloe, Matthias Keller, and Stefan Zahler

Calpains: a physiological regulator of the endothelial barrier?
Am J Physiol Heart Circ Physiol 290: H2035-H2042, 2006. First published December 22, 2005; doi:10.1152/ajpheart.00772.2004 [Abstract] [Full Text] [PDF]  

Maria A. Cavasin, Zhen-Yin Tao, Ai-Li Yu, and Xiao-Ping Yang

Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function
Am J Physiol Heart Circ Physiol 290: H2043-H2050, 2006. First published December 16, 2005; doi:10.1152/ajpheart.01121.2005 [Abstract] [Full Text] [PDF]  

Jeanna Jacobi, Shifra Sela, Hector I. Cohen, Judith Chezar, and Batya Kristal

Priming of polymorphonuclear leukocytes: a culprit in the initiation of endothelial cell injury
Am J Physiol Heart Circ Physiol 290: H2051-H2058, 2006. First published December 30, 2005; doi:10.1152/ajpheart.01040.2005 [Abstract] [Full Text] [PDF]  

Alfred A. Lanzafame, Lynne Turnbull, Fatemeh Amiramahdi, Jane F. Arthur, Huy Huynh, and Elizabeth A. Woodcock

Inositol phospholipids localized to caveolae in rat heart are regulated by ₁-adrenergic receptors and by ischemia-reperfusion
Am J Physiol Heart Circ Physiol 290: H2059-H2065, 2006. First published December 22, 2005; doi:10.1152/ajpheart.01210.2005 [Abstract] [Full Text] [PDF]  

Jefferson C. Frisbee

Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats
Am J Physiol Heart Circ Physiol 290: H2066-H2074, 2006. First published December 22, 2005; doi:10.1152/ajpheart.01251.2005 [Abstract] [Full Text] [PDF]  

Youngran Chung

Oxygen reperfusion is limited in the postischemic hypertrophic myocardium
Am J Physiol Heart Circ Physiol 290: H2075-H2084, 2006; doi:10.1152/ajpheart.00619.2005 [Abstract] [Full Text] [PDF]  

Olivia Manfrini, Gabriele Bazzocchi, Alessandra Luati, Alberigo Borghi, Paola Monari, and Raffaele Bugiardini

Coronary spasm reflects inputs from adjacent esophageal system
Am J Physiol Heart Circ Physiol 290: H2085-H2091, 2006. First published December 30, 2005; doi:10.1152/ajpheart.00925.2005 [Abstract] [Full Text] [PDF]  

Kenneth D. Varian, Sripriya Raman, and Paul M. L. Janssen

Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae
Am J Physiol Heart Circ Physiol 290: H2092-H2097, 2006; doi:10.1152/ajpheart.01241.2005 [Abstract] [Full Text] [PDF]  

Polina S. Petkova-Kirova, Erdal Gursoy, Haider Mehdi, Charles F. McTiernan, Barry London, and Guy Salama

Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-
Am J Physiol Heart Circ Physiol 290: H2098-H2107, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00097.2005 [Abstract] [Full Text] [PDF]  

B. Å. Borge, V. V. Iversen, and R. K. Reed

Changes in plasma protein extravasation in rat skin during inflammatory challenges evaluated by microdialysis
Am J Physiol Heart Circ Physiol 290: H2108-H2115, 2006. First published December 22, 2005; doi:10.1152/ajpheart.00395.2005 [Abstract] [Full Text] [PDF]  

Yangxin Li, Yao-Hua Song, Jessica Mohler, and Patrick Delafontaine

ANG II induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression
Am J Physiol Heart Circ Physiol 290: H2116-H2123, 2006. First published December 9, 2005; doi:10.1152/ajpheart.00551.2005 [Abstract] [Full Text] [PDF]  

Natalia I. Gokina and Tara Goecks

Upregulation of endothelial cell Ca²⁺ signaling contributes to pregnancy-enhanced vasodilation of rat uteroplacental arteries
Am J Physiol Heart Circ Physiol 290: H2124-H2135, 2006. First published December 3, 2005; doi:10.1152/ajpheart.00813.2005 [Abstract] [Full Text] [PDF]  

Mahmood Khan, Saradhadevi Varadharaj, Latha P. Ganesan, Jagdish C. Shobha, Madireddi U. Naidu, Narasimham L. Parinandi, Susheela Tridandapani, Vijay Kumar Kutala, and Periannan Kuppusamy

C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling
Am J Physiol Heart Circ Physiol 290: H2136-H2145, 2006. First published December 22, 2005; doi:10.1152/ajpheart.01072.2005 [Abstract] [Full Text] [PDF]  

Subrina Jesmin, Yuichi Hattori, Seiji Maeda, Sohel Zaedi, Ichiro Sakuma, and Takashi Miyauchi

Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats
Am J Physiol Heart Circ Physiol 290: H2146-H2154, 2006. First published December 30, 2005; doi:10.1152/ajpheart.01142.2005 [Abstract] [Full Text] [PDF]  

Cecilia Hurtado, Michele Prociuk, Thane G. Maddaford, Elena Dibrov, Nasrin Mesaeli, Larry V. Hryshko, and Grant N. Pierce

Cells expressing unique Na⁺/Ca²⁺ exchange (NCX1) splice variants exhibit different susceptibilities to Ca²⁺ overload
Am J Physiol Heart Circ Physiol 290: H2155-H2162, 2006. First published January 6, 2006; doi:10.1152/ajpheart.00958.2005 [Abstract] [Full Text] [PDF]  

CORRIGENDA:

Corrigendum
Am J Physiol Heart Circ Physiol 290: H2163-H2163, 2006; doi:10.1152/ajpheart.00192.2006 [Full Text] [PDF]  

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