CALL FOR PAPERS:

Sándor Bátkai, Mohanraj Rajesh, Partha Mukhopadhyay, György Haskó, Lucas Liaudet, Benjamin F. Cravatt, Anna Csiszár, Zoltan Ungvári, and Pál Pacher

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase
Am J Physiol Heart Circ Physiol 293: H909-H918, 2007. First published April 13, 2007; doi:10.1152/ajpheart.00373.2007 [Abstract] [Full Text] [PDF]  

Anna Csiszar, Nazar Labinskyy, Zsuzsanna Orosz, Zhao Xiangmin, Rochelle Buffenstein, and Zoltan Ungvari

Vascular aging in the longest-living rodent, the naked mole rat
Am J Physiol Heart Circ Physiol 293: H919-H927, 2007. First published April 27, 2007; doi:10.1152/ajpheart.01287.2006 [Abstract] [Full Text] [PDF]  

EDITORIAL FOCUS:

Christopher P. Baines

Editorial Focus  The mitochondrial permeability transition pore as a target of cardioprotective signaling
Am J Physiol Heart Circ Physiol 293: H903-H904, 2007. First published May 18, 2007; doi:10.1152/ajpheart.00575.2007 [Full Text] [PDF]  

Richard Re

Editorial Focus  Intracellular renin-angiotensin system: the tip of the intracrine physiology iceberg
Am J Physiol Heart Circ Physiol 293: H905-H906, 2007. First published May 25, 2007; doi:10.1152/ajpheart.00552.2007 [Full Text] [PDF]  

Aisha Frazier and Anne M. Murphy

Editorial Focus  Repairing the myofilaments to heal the heart
Am J Physiol Heart Circ Physiol 293: H907-H908, 2007. First published April 6, 2007; doi:10.1152/ajpheart.00272.2007 [Full Text] [PDF]  

ARTICLES:

Paul A. Townsend, Sean M. Davidson, Samantha J. Clarke, Igor Khaliulin, Christopher J. Carroll, Tiziano M. Scarabelli, Richard A. Knight, Anastasis Stephanou, David S. Latchman, and Andrew P. Halestrap

Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress
Am J Physiol Heart Circ Physiol 293: H928-H938, 2007. First published May 4, 2007; doi:10.1152/ajpheart.01135.2006 [Abstract] [Full Text] [PDF]  

Vivek P. Singh, Bao Le, Vadiraja B. Bhat, Kenneth M. Baker, and Rajesh Kumar

High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes
Am J Physiol Heart Circ Physiol 293: H939-H948, 2007. First published May 4, 2007; doi:10.1152/ajpheart.00391.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Ganapathy Jagatheesan, Sudarsan Rajan, Natalia Petrashevskaya, Arnold Schwartz, Greg Boivin, Grace M. Arteaga, R. John Solaro, Stephen B. Liggett, and David F. Wieczorek

Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis
Am J Physiol Heart Circ Physiol 293: H949-H958, 2007. First published April 6, 2007; doi:10.1152/ajpheart.01341.2006 [Abstract] [Full Text] [PDF]  

Zhi-Yong Chen, Guo-Gang Feng, Kimitoshi Nishiwaki, Yasuhiro Shimada, Yoshihiro Fujiwara, Toru Komatsu, and Naohisa Ishikawa

Possible roles of neuropeptide Y Y₃-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction
Am J Physiol Heart Circ Physiol 293: H959-H967, 2007. First published March 30, 2007; doi:10.1152/ajpheart.00886.2006 [Abstract] [Full Text] [PDF]  

Tsung-Ming Lee, Mei-Shu Lin, and Nen-Chung Chang

Inhibition of histone deacetylase on ventricular remodeling in infarcted rats
Am J Physiol Heart Circ Physiol 293: H968-H977, 2007. First published March 30, 2007; doi:10.1152/ajpheart.00891.2006 [Abstract] [Full Text] [PDF]  

Jen-Ying Deng, Jiung-Pang Huang, Long-Sheng Lu, and Li-Man Hung

Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats
Am J Physiol Heart Circ Physiol 293: H978-H987, 2007. First published March 30, 2007; doi:10.1152/ajpheart.01002.2006 [Abstract] [Full Text] [PDF]  

D. Konrad, M. Haney, G. Johansson, M. Wanecek, E. Weitzberg, and A. Oldner

Cardiac effects of endothelin receptor antagonism in endotoxemic pigs
Am J Physiol Heart Circ Physiol 293: H988-H996, 2007. First published March 30, 2007; doi:10.1152/ajpheart.01023.2006 [Abstract] [Full Text] [PDF]  

Min Lin, Rugao Liu, David Gozal, William B. Wead, Mark W. Chapleau, Robert Wurster, and Zixi (Jack) Cheng

Chronic intermittent hypoxia impairs baroreflex control of heart rate but enhances heart rate responses to vagal efferent stimulation in anesthetized mice
Am J Physiol Heart Circ Physiol 293: H997-H1006, 2007. First published March 23, 2007; doi:10.1152/ajpheart.01124.2006 [Abstract] [Full Text] [PDF]  

Susana M. Mosca

Cardioprotective effects of stretch are mediated by activation of sarcolemmal, not mitochondrial, ATP-sensitive potassium channels
Am J Physiol Heart Circ Physiol 293: H1007-H1012, 2007. First published March 30, 2007; doi:10.1152/ajpheart.00051.2007 [Abstract] [Full Text] [PDF]  

A. L. T. Uusitalo, E. Vanninen, E. Levälahti, M. C. Battié, T. Videman, and J. Kaprio

Role of genetic and environmental influences on heart rate variability in middle-aged men
Am J Physiol Heart Circ Physiol 293: H1013-H1022, 2007. First published March 30, 2007; doi:10.1152/ajpheart.00475.2006 [Abstract] [Full Text] [PDF]  

Yu Yao, Aleksandr Rabodzey, and C. Forbes Dewey, Jr.

Glycocalyx modulates the motility and proliferative response of vascular endothelium to fluid shear stress
Am J Physiol Heart Circ Physiol 293: H1023-H1030, 2007. First published April 27, 2007; doi:10.1152/ajpheart.00162.2007 [Abstract] [Full Text] [PDF]  

A. D. Augst, B. Ariff, S. A. G. McG. Thom, X. Y. Xu, and A. D. Hughes

Analysis of complex flow and the relationship between blood pressure, wall shear stress, and intima-media thickness in the human carotid artery
Am J Physiol Heart Circ Physiol 293: H1031-H1037, 2007. First published April 20, 2007; doi:10.1152/ajpheart.00989.2006 [Abstract] [Full Text] [PDF]  

Eileen M. Finnegan, Gilda A. Barabino, Xiao-du Liu, Hee-Yoon Chang, Alfred Jonczyk, and Dhananjay K. Kaul

Small-molecule cyclic V3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion
Am J Physiol Heart Circ Physiol 293: H1038-H1045, 2007. First published May 4, 2007; doi:10.1152/ajpheart.01054.2006 [Abstract] [Full Text] [PDF]  

Mathieu Gautier, Daniel Antier, Pierre Bonnet, Jean-Loic Le Net, Gilles Hanton, and Veronique Eder

Continuous inhalation of carbon monoxide induces right ventricle ischemia and dysfunction in rats with hypoxic pulmonary hypertension
Am J Physiol Heart Circ Physiol 293: H1046-H1052, 2007. First published May 4, 2007; doi:10.1152/ajpheart.01040.2006 [Abstract] [Full Text] [PDF]  

Vanja Drobic, Ryan H. Cunnington, Kristen M. Bedosky, Joshua E. Raizman, Vinit V. Elimban, Sunil G. Rattan, and Ian M. C. Dixon

Differential and combined effects of cardiotrophin-1 and TGF-₁ on cardiac myofibroblast proliferation and contraction
Am J Physiol Heart Circ Physiol 293: H1053-H1064, 2007. First published May 4, 2007; doi:10.1152/ajpheart.00935.2006 [Abstract] [Full Text] [PDF]  

Kevin C. Doerschug, Angela S. Delsing, Gregory A. Schmidt, and William G. Haynes

Impairments in microvascular reactivity are related to organ failure in human sepsis
Am J Physiol Heart Circ Physiol 293: H1065-H1071, 2007. First published May 4, 2007; doi:10.1152/ajpheart.01237.2006 [Abstract] [Full Text] [PDF]  

Sharyn M. Fitzgerald, Homaira Bashari, Jessica A. Cox, Helena C. Parkington, and Roger G. Evans

Contributions of endothelium-derived relaxing factors to control of hindlimb blood flow in the mouse in vivo
Am J Physiol Heart Circ Physiol 293: H1072-H1082, 2007. First published April 27, 2007; doi:10.1152/ajpheart.00072.2007 [Abstract] [Full Text] [PDF]  

Vera Farah, Khalid M. Elased, and Mariana Morris

Genetic and dietary interactions: role of angiotensin AT_1a receptors in response to a high-fructose diet
Am J Physiol Heart Circ Physiol 293: H1083-H1089, 2007. First published April 20, 2007; doi:10.1152/ajpheart.00106.2006 [Abstract] [Full Text] [PDF]  

Lacy A. Holowatz and W. Larry Kenney

Local ascorbate administration augments NO- and non-NO-dependent reflex cutaneous vasodilation in hypertensive humans
Am J Physiol Heart Circ Physiol 293: H1090-H1096, 2007. First published May 4, 2007; doi:10.1152/ajpheart.00295.2007 [Abstract] [Full Text] [PDF]  

Aleksander S. Golub, Matthew C. Barker, and Roland N. Pittman

PO₂ profiles near arterioles and tissue oxygen consumption in rat mesentery
Am J Physiol Heart Circ Physiol 293: H1097-H1106, 2007. First published May 4, 2007; doi:10.1152/ajpheart.00077.2007 [Abstract] [Full Text] [PDF]  

Jagdip S. Jaswal, Manoj Gandhi, Barry A. Finegan, Jason R. B. Dyck, and Alexander S. Clanachan

Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization
Am J Physiol Heart Circ Physiol 293: H1107-H1114, 2007. First published May 11, 2007; doi:10.1152/ajpheart.00455.2007 [Abstract] [Full Text] [PDF]  

Bonnie L. Goodwin, Laura C. Pendleton, Monique M. Levy, Larry P. Solomonson, and Duane C. Eichler

Tumor necrosis factor- reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells
Am J Physiol Heart Circ Physiol 293: H1115-H1121, 2007. First published May 11, 2007; doi:10.1152/ajpheart.01100.2006 [Abstract] [Full Text] [PDF]  

William J. Hucker, Vinod Sharma, Vladimir P. Nikolski, and Igor R. Efimov

Atrioventricular conduction with and without AV nodal delay: two pathways to the bundle of His in the rabbit heart
Am J Physiol Heart Circ Physiol 293: H1122-H1130, 2007. First published May 11, 2007; doi:10.1152/ajpheart.00115.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]  

Olga V. Glinskii, Tsghe W. Abraha, James R. Turk, Leona J. Rubin, Virginia H. Huxley, and Vladislav V. Glinsky

Microvascular network remodeling in dura mater of ovariectomized pigs: role for angiopoietin-1 in estrogen-dependent control of vascular stability
Am J Physiol Heart Circ Physiol 293: H1131-H1137, 2007. First published May 11, 2007; doi:10.1152/ajpheart.01156.2006 [Abstract] [Full Text] [PDF]  

Elhadi H. Aburawi, Ansgar Berg, Petru Liuba, and Erkki Pesonen

Effects of cardiopulmonary bypass surgery on coronary flow in children assessed with transthoracic Doppler echocardiography
Am J Physiol Heart Circ Physiol 293: H1138-H1143, 2007. First published May 4, 2007; doi:10.1152/ajpheart.00025.2007 [Abstract] [Full Text] [PDF]  

Elza D. van Deel, Daphne Merkus, Rien van Haperen, Monique C. de Waard, Rini de Crom, and Dirk J. Duncker

Vasomotor control in mice overexpressing human endothelial nitric oxide synthase
Am J Physiol Heart Circ Physiol 293: H1144-H1153, 2007. First published May 11, 2007; doi:10.1152/ajpheart.00773.2006 [Abstract] [Full Text] [PDF]  

Jorge F. Giani, Mariela M. Gironacci, Marina C. Muñoz, Clara Peña, Daniel Turyn, and Fernando P. Dominici

Angiotensin-(1–7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT₁ and Mas receptors
Am J Physiol Heart Circ Physiol 293: H1154-H1163, 2007. First published May 11, 2007; doi:10.1152/ajpheart.01395.2006 [Abstract] [Full Text] [PDF]  

Mohammad W. Mohiuddin, Glen A. Laine, and Christopher M. Quick

Increase in pulse wavelength causes the systemic arterial tree to degenerate into a classical windkessel
Am J Physiol Heart Circ Physiol 293: H1164-H1171, 2007. First published May 4, 2007; doi:10.1152/ajpheart.00133.2007 [Abstract] [Full Text] [PDF]  

Tracy J. Pritchard, Michelle Parvatiyar, Daniel P. Bullard, Ronald M. Lynch, John N. Lorenz, and Richard J. Paul

Transgenic mice expressing Na⁺-K⁺-ATPase in smooth muscle decreases blood pressure
Am J Physiol Heart Circ Physiol 293: H1172-H1182, 2007. First published April 27, 2007; doi:10.1152/ajpheart.00279.2007 [Abstract] [Full Text] [PDF]  

Arun M. Venugopal, Randolph H. Stewart, Glen A. Laine, Ranjeet M. Dongaonkar, and Christopher M. Quick

Lymphangion coordination minimally affects mean flow in lymphatic vessels
Am J Physiol Heart Circ Physiol 293: H1183-H1189, 2007. First published April 27, 2007; doi:10.1152/ajpheart.01340.2006 [Abstract] [Full Text] [PDF]  

Jihong Xing, Satoshi Koba, Valerie Kehoe, Zhaohui Gao, Kristen Rice, Nicholas King, Lawrence Sinoway, and Jianhua Li

Interstitial norepinephrine concentrations in skeletal muscle of ischemic heart failure
Am J Physiol Heart Circ Physiol 293: H1190-H1195, 2007. First published April 20, 2007; doi:10.1152/ajpheart.00231.2007 [Abstract] [Full Text] [PDF]  

Virginia H. Huxley, Jian Jie Wang, and Ingrid H. Sarelius

Adaptation of coronary microvascular exchange in arterioles and venules to exercise training and a role for sex in determining permeability responses
Am J Physiol Heart Circ Physiol 293: H1196-H1205, 2007. First published April 13, 2007; doi:10.1152/ajpheart.00069.2007 [Abstract] [Full Text] [PDF]  

Pedro Cabrales

Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia
Am J Physiol Heart Circ Physiol 293: H1206-H1215, 2007. First published April 20, 2007; doi:10.1152/ajpheart.00109.2007 [Abstract] [Full Text] [PDF]  

David B. Murray, Jason D. Gardner, Scott P. Levick, Gregory L. Brower, Loren G. Morgan, and Joseph S. Janicki

Response of cardiac mast cells to atrial natriuretic peptide
Am J Physiol Heart Circ Physiol 293: H1216-H1222, 2007. First published April 13, 2007; doi:10.1152/ajpheart.01388.2006 [Abstract] [Full Text] [PDF]  

Fadi G. Akar, Robert D. Nass, Samuel Hahn, Eugenio Cingolani, Manish Shah, Geoffrey G. Hesketh, Deborah DiSilvestre, Richard S. Tunin, David A. Kass, and Gordon F. Tomaselli

Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure
Am J Physiol Heart Circ Physiol 293: H1223-H1230, 2007. First published April 13, 2007; doi:10.1152/ajpheart.00079.2007 [Abstract] [Full Text] [PDF] [Supplemental Table and Video]  

Kyungmoo Ryu, Li Li, Celeen M. Khrestian, Naomichi Matsumoto, Jayakumar Sahadevan, Mary L. Ruehr, David R. Van Wagoner, Igor R. Efimov, and Albert L. Waldo

Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmias
Am J Physiol Heart Circ Physiol 293: H1231-H1241, 2007. First published April 13, 2007; doi:10.1152/ajpheart.00607.2006 [Abstract] [Full Text] [PDF]  

Robert Fischer, Ralf Dechend, Andrej Gapelyuk, Erdenechimeg Shagdarsuren, Konstanze Gruner, Andreas Gruner, Petra Gratze, Fatimunnisa Qadri, Maren Wellner, Anette Fiebeler, Rainer Dietz, Friedrich C. Luft, Dominik N. Muller, and Alexander Schirdewan

Angiotensin II-induced sudden arrhythmic death and electrical remodeling
Am J Physiol Heart Circ Physiol 293: H1242-H1253, 2007. First published April 6, 2007; doi:10.1152/ajpheart.01400.2006 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Taku Yamamoto, Takeshi Shirayama, Tomohiko Sakatani, Tomosaburo Takahashi, Hideo Tanaka, Tetsuro Takamatsu, Kenneth W. Spitzer, and Hiroaki Matsubara

Enhanced activity of ventricular Na⁺-HCO₃^– cotransport in pressure overload hypertrophy
Am J Physiol Heart Circ Physiol 293: H1254-H1264, 2007. First published April 6, 2007; doi:10.1152/ajpheart.00964.2006 [Abstract] [Full Text] [PDF]  

Antoine Ayer, Vladan Antic, Abdul G. Dulloo, Bruce N. Van Vliet, and Jean-Pierre Montani

Hemodynamic consequences of chronic parasympathetic blockade with a peripheral muscarinic antagonist
Am J Physiol Heart Circ Physiol 293: H1265-H1272, 2007. First published May 11, 2007; doi:10.1152/ajpheart.00326.2007 [Abstract] [Full Text] [PDF]  

Jing Liu, Jianfeng Du, Chi Zhang, Jeffery W. Walker, and Xupei Huang

Progressive troponin I loss impairs cardiac relaxation and causes heart failure in mice
Am J Physiol Heart Circ Physiol 293: H1273-H1281, 2007. First published May 25, 2007; doi:10.1152/ajpheart.01379.2006 [Abstract] [Full Text] [PDF]  

Baiqiu Wang, Amer Omar, Tatjana Angelovska, Vanja Drobic, Sunil G. Rattan, Stephen C. Jones, and Ian M. C. Dixon

Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts
Am J Physiol Heart Circ Physiol 293: H1282-H1290, 2007. First published May 18, 2007; doi:10.1152/ajpheart.00910.2006 [Abstract] [Full Text] [PDF]  

Amy K. L. Banes-Berceli, Pimonrat Ketsawatsomkron, Safia Ogbi, Bela Patel, David M. Pollock, and Mario B. Marrero

Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation
Am J Physiol Heart Circ Physiol 293: H1291-H1299, 2007. First published May 25, 2007; doi:10.1152/ajpheart.00181.2007 [Abstract] [Full Text] [PDF]  

Ivo R. Henkens, Koen T. B. Mouchaers, Hubert W. Vliegen, Willem J. van der Laarse, Cees A. Swenne, Arie C. Maan, Harmen H. M. Draisma, Ingrid Schalij, Ernst E. van der Wall, Martin J. Schalij, and Anton Vonk-Noordegraaf

Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography
Am J Physiol Heart Circ Physiol 293: H1300-H1307, 2007. First published May 11, 2007; doi:10.1152/ajpheart.01359.2006 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Piercarlo Ballo, Arianna Bocelli, and Sergio Mondillo

What is the actual contribution of atrioventricular plane displacement to left ventricular stroke volume?
Am J Physiol Heart Circ Physiol 293: H1315-H1315, 2007; doi:10.1152/ajpheart.00437.2007 [Full Text] [PDF]  

Marcus Carlsson, Martin Ugander, and Hakan Arheden

REPLY
Am J Physiol Heart Circ Physiol 293: H1316-H1316, 2007; doi:10.1152/ajpheart.00506.2007 [Full Text] [PDF]  

REPORTS:

Dinender K. Singla, Gary E. Lyons, and Timothy J. Kamp

Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling
Am J Physiol Heart Circ Physiol 293: H1308-H1314, 2007. First published April 6, 2007; doi:10.1152/ajpheart.01277.2006 [Abstract] [Full Text] [PDF]  

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