AJP - Heart and Circulatory Physiology -- Table of Contents (April 1 2008, 294 [4])

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Wei Zheng, Hong Ji, Christine Maric, Xie Wu, and Kathryn Sandberg: Effect of dietary sodium on estrogen regulation of blood pressure in Dahl salt-sensitive rats
Am J Physiol Heart Circ Physiol 294: H1508-H1513, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01322.2007 [Abstract] [Full Text] [PDF]

James R. Bell, Enzo R. Porrello, Catherine E. Huggins, Stephen B. Harrap, and Lea M. D. Delbridge: The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy
Am J Physiol Heart Circ Physiol 294: H1514-H1522, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01283.2007 [Abstract] [Full Text] [PDF]

Heidi L. Lujan and Stephen E. DiCarlo: Sex differences to myocardial ischemia and β-adrenergic receptor blockade in conscious rats
Am J Physiol Heart Circ Physiol 294: H1523-H1529, 2008. First published February 8, 2008; doi:10.1152/ajpheart.01241.2007 [Abstract] [Full Text] [PDF]

Mark J. Crabtree, Caroline L. Smith, George Lam, Michael S. Goligorsky, and Steven S. Gross: Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS
Am J Physiol Heart Circ Physiol 294: H1530-H1540, 2008. First published January 11, 2008; doi:10.1152/ajpheart.00823.2007 [Abstract] [Full Text] [PDF]

EDITORIAL FOCUS:

Ion S. Jovin and Frank J. Giordano: Differentiation by association: is a cell's fate determined by the company it keeps?
Am J Physiol Heart Circ Physiol 294: H1503-H1504, 2008. First published February 22, 2008; doi:10.1152/ajpheart.00138.2008 [Full Text] [PDF]

Linda K. McLoon: Focusing on fibrosis: halofuginone-induced functional improvement in the mdx mouse model of Duchenne muscular dystrophy
Am J Physiol Heart Circ Physiol 294: H1505-H1507, 2008. First published February 29, 2008; doi:10.1152/ajpheart.00176.2008 [Full Text] [PDF]

ARTICLES:

Alessia Orlandi, Francesca Pagani, Daniele Avitabile, Giuseppina Bonanno, Giovanni Scambia, Elisa Vigna, Francesca Grassi, Fabrizio Eusebi, Sergio Fucile, Maurizio Pesce, and Maurizio C. Capogrossi: Functional properties of cells obtained from human cord blood CD34⁺ stem cells and mouse cardiac myocytes in coculture
Am J Physiol Heart Circ Physiol 294: H1541-H1549, 2008. First published January 25, 2008; doi:10.1152/ajpheart.01285.2007 [Abstract] [Full Text] [PDF] [Supplemental Figure and Movie]

Kyla D. Huebner, Davinder S. Jassal, Orna Halevy, Mark Pines, and Judy E. Anderson: Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone
Am J Physiol Heart Circ Physiol 294: H1550-H1561, 2008. First published February 8, 2008; doi:10.1152/ajpheart.01253.2007 [Abstract] [Full Text] [PDF] [Supplemental Videos]

Hélène Bulckaen, Gaétan Prévost, Eric Boulanger, Géraldine Robitaille, Valérie Roquet, Cédric Gaxatte, Guillaume Garçon, Bruno Corman, Pierre Gosset, Pirouz Shirali, Colette Creusy, and François Puisieux: Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging
Am J Physiol Heart Circ Physiol 294: H1562-H1570, 2008. First published January 25, 2008; doi:10.1152/ajpheart.00241.2007 [Abstract] [Full Text] [PDF]

Roselle Gélinas, François Labarthe, Bertrand Bouchard, Janie Mc Duff, Guy Charron, Martin E. Young, and Christine Des Rosiers: Alterations in carbohydrate metabolism and its regulation in PPAR ${alpha}$ null mouse hearts
Am J Physiol Heart Circ Physiol 294: H1571-H1580, 2008. First published January 25, 2008; doi:10.1152/ajpheart.01340.2007 [Abstract] [Full Text] [PDF]

S. J. Swoap, C. Li, J. Wess, A. D. Parsons, T. D. Williams, and J. M. Overton: Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
Am J Physiol Heart Circ Physiol 294: H1581-H1588, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01000.2007 [Abstract] [Full Text] [PDF]

Charles S. Chung and Sándor J. Kovács: Physical determinants of left ventricular isovolumic pressure decline: model prediction with in vivo validation
Am J Physiol Heart Circ Physiol 294: H1589-H1596, 2008. First published January 25, 2008; doi:10.1152/ajpheart.00990.2007 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Victor A. Maltsev, Vitaliy Reznikov, Nidas A. Undrovinas, Hani N. Sabbah, and Albertas Undrovinas: Modulation of late sodium current by Ca²⁺, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences
Am J Physiol Heart Circ Physiol 294: H1597-H1608, 2008. First published January 18, 2008; doi:10.1152/ajpheart.00484.2007 [Abstract] [Full Text] [PDF]

Vijay Sharma, Pavan Dhillon, Richard Wambolt, Hannah Parsons, Roger Brownsey, Michael F. Allard, and John H. McNeill: Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat
Am J Physiol Heart Circ Physiol 294: H1609-H1620, 2008. First published January 18, 2008; doi:10.1152/ajpheart.00949.2007 [Abstract] [Full Text] [PDF]

Thomas J. Calvert, Louis G. Chicoine, Yusen Liu, and Leif D. Nelin: Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin
Am J Physiol Heart Circ Physiol 294: H1621-H1629, 2008. First published February 15, 2008; doi:10.1152/ajpheart.01008.2007 [Abstract] [Full Text] [PDF]

Jessica R. Meendering, Britta N. Torgrimson, Nicole P. Miller, Paul F. Kaplan, and Christopher T. Minson: Estrogen, medroxyprogesterone acetate, endothelial function, and biomarkers of cardiovascular risk in young women
Am J Physiol Heart Circ Physiol 294: H1630-H1637, 2008. First published February 15, 2008; doi:10.1152/ajpheart.01314.2007 [Abstract] [Full Text] [PDF]

Vít Jakoubek, Jana Bíbová, Jan Herget, and Václav Hampl: Chronic hypoxia increases fetoplacental vascular resistance and vasoconstrictor reactivity in the rat
Am J Physiol Heart Circ Physiol 294: H1638-H1644, 2008. First published February 29, 2008; doi:10.1152/ajpheart.01120.2007 [Abstract] [Full Text] [PDF]

Shahzad Munir, Benyu Jiang, Antoine Guilcher, Sally Brett, Simon Redwood, Michael Marber, and Philip Chowienczyk: Exercise reduces arterial pressure augmentation through vasodilation of muscular arteries in humans
Am J Physiol Heart Circ Physiol 294: H1645-H1650, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01171.2007 [Abstract] [Full Text] [PDF]

B. A. Kaufmann, A. M. Bernheim, S. Kiencke, M. Fischler, J. Sklenar, H. Mairbäurl, M. Maggiorini, and H. P. Brunner-La Rocca: Evidence supportive of impaired myocardial blood flow reserve at high altitude in subjects developing high-altitude pulmonary edema
Am J Physiol Heart Circ Physiol 294: H1651-H1657, 2008. First published February 29, 2008; doi:10.1152/ajpheart.00760.2007 [Abstract] [Full Text] [PDF]

Lusha Xiang, Jennifer Dearman, Sean R. Abram, Cory Carter, and Robert L. Hester: Insulin resistance and impaired functional vasodilation in obese Zucker rats
Am J Physiol Heart Circ Physiol 294: H1658-H1666, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01206.2007 [Abstract] [Full Text] [PDF]

Zhyldyz Kabaeva, Mei Zhao, and Daniel E. Michele: Blebbistatin extends culture life of adult mouse cardiac myocytes and allows efficient and stable transgene expression
Am J Physiol Heart Circ Physiol 294: H1667-H1674, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01144.2007 [Abstract] [Full Text] [PDF]

Vivek P. Singh, Kenneth M. Baker, and Rajesh Kumar: Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production
Am J Physiol Heart Circ Physiol 294: H1675-H1684, 2008. First published February 22, 2008; doi:10.1152/ajpheart.91493.2007 [Abstract] [Full Text] [PDF]

Gary P. Van Guilder, Brian L. Stauffer, Jared J. Greiner, and Christopher A. DeSouza: Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists
Am J Physiol Heart Circ Physiol 294: H1685-H1692, 2008. First published February 15, 2008; doi:10.1152/ajpheart.01281.2007 [Abstract] [Full Text] [PDF]

Oleg A. Palygin, Janette M. Pettus, and Erwin F. Shibata: Regulation of caveolar cardiac sodium current by a single G_s ${alpha}$ histidine residue
Am J Physiol Heart Circ Physiol 294: H1693-H1699, 2008. First published February 15, 2008; doi:10.1152/ajpheart.01337.2007 [Abstract] [Full Text] [PDF] [Supplemental Material]

Kuniyuki Nakamura, Masahiro Kamouchi, Takanari Kitazono, Junya Kuroda, Ryu Matsuo, Noriko Hagiwara, Eiichi Ishikawa, Hiroaki Ooboshi, Setsuro Ibayashi, and Mitsuo Iida: Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes
Am J Physiol Heart Circ Physiol 294: H1700-H1707, 2008. First published February 8, 2008; doi:10.1152/ajpheart.01203.2007 [Abstract] [Full Text] [PDF]

Shinichi Sato: Quantitative evaluation of ontogenetic change in heart rate and its autonomic regulation in newborn mice with the use of a noninvasive piezoelectric sensor
Am J Physiol Heart Circ Physiol 294: H1708-H1715, 2008. First published February 8, 2008; doi:10.1152/ajpheart.01122.2007 [Abstract] [Full Text] [PDF]

Ulrich Gergs, Peter Boknik, Wilhelm Schmitz, Andreas Simm, Rolf-Edgar Silber, and Joachim Neumann: A positive inotropic effect of ATP in the human cardiac atrium
Am J Physiol Heart Circ Physiol 294: H1716-H1723, 2008. First published February 8, 2008; doi:10.1152/ajpheart.00945.2007 [Abstract] [Full Text] [PDF]

Steven N. Mink, Krika Kasian, Luis E. Santos Martinez, Hans Jacobs, Ratna Bose, Zhao-Qin Cheng, and R. Bruce Light: Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation
Am J Physiol Heart Circ Physiol 294: H1724-H1735, 2008. First published February 8, 2008; doi:10.1152/ajpheart.01072.2007 [Abstract] [Full Text] [PDF]

C. D. Venkatakrishnan, Kathy Dunsmore, Hector Wong, Sashwathi Roy, Chandan K. Sen, Altaf Wani, Jay L. Zweier, and Govindasamy Ilangovan: HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G₂/M phase cell cycle arrest
Am J Physiol Heart Circ Physiol 294: H1736-H1744, 2008. First published February 8, 2008; doi:10.1152/ajpheart.91507.2007 [Abstract] [Full Text] [PDF]

A. Elizabeth Linder, Jessica Diaz, Wei Ni, Theo Szasz, Robert Burnett, and Stephanie W. Watts: Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat
Am J Physiol Heart Circ Physiol 294: H1745-H1752, 2008. First published February 8, 2008; doi:10.1152/ajpheart.91415.2007 [Abstract] [Full Text] [PDF]

Bruno Taccardi, Bonnie B. Punske, Emilio Macchi, Robert S. MacLeod, and Philip R. Ershler: Epicardial and intramural excitation during ventricular pacing: effect of myocardial structure
Am J Physiol Heart Circ Physiol 294: H1753-H1766, 2008. First published February 8, 2008; doi:10.1152/ajpheart.01400.2007 [Abstract] [Full Text] [PDF]

M. Pho, W. Lee, D. R. Watt, C. Laschinger, C. A. Simmons, and C. A. McCulloch: Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves
Am J Physiol Heart Circ Physiol 294: H1767-H1778, 2008. First published February 8, 2008; doi:10.1152/ajpheart.01305.2007 [Abstract] [Full Text] [PDF]

Alexander H. Penn and Geert W. Schmid-Schönbein: The intestine as source of cytotoxic mediators in shock: free fatty acids and degradation of lipid-binding proteins
Am J Physiol Heart Circ Physiol 294: H1779-H1792, 2008. First published February 8, 2008; doi:10.1152/ajpheart.00902.2007 [Abstract] [Full Text] [PDF]

Kimberly P. Gannon, Lauren G. VanLandingham, Nikki L. Jernigan, Samira C. Grifoni, Gina Hamilton, and Heather A. Drummond: Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice
Am J Physiol Heart Circ Physiol 294: H1793-H1803, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01380.2007 [Abstract] [Full Text] [PDF]

Arintaya Phrommintikul, Lavinia Tran, Andrew Kompa, Bing Wang, Anastasia Adrahtas, Danielle Cantwell, Darren J. Kelly, and Henry Krum: Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction
Am J Physiol Heart Circ Physiol 294: H1804-H1814, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01078.2007 [Abstract] [Full Text] [PDF]

Yining Yang, Yitong Ma, Wei Han, Jun Li, Yang Xiang, Fen Liu, Xiang Ma, JianFa Zhang, Zhenyan Fu, Yi-Dan Su, Xiao-Jun Du, and Xiao-Ming Gao: Age-related differences in postinfarct left ventricular rupture and remodeling
Am J Physiol Heart Circ Physiol 294: H1815-H1822, 2008. First published February 8, 2008; doi:10.1152/ajpheart.00831.2007 [Abstract] [Full Text] [PDF]

Alexey Aleshin, Radha Ananthakrishnan, Qing Li, Rosa Rosario, Yan Lu, Wu Qu, Fei Song, Soliman Bakr, Matthias Szabolcs, Vivette D'Agati, Rui Liu, Shunichi Homma, Ann Marie Schmidt, Shi Fang Yan, and Ravichandran Ramasamy: RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model
Am J Physiol Heart Circ Physiol 294: H1823-H1832, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01210.2007 [Abstract] [Full Text] [PDF]

S. C. Newcomer, C. L. Sauder, N. T. Kuipers, M. H. Laughlin, and C. A. Ray: Effects of posture on shear rates in human brachial and superficial femoral arteries
Am J Physiol Heart Circ Physiol 294: H1833-H1839, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01108.2007 [Abstract] [Full Text] [PDF]

Lisa A. Lesniewski, Anthony J. Donato, Bradley J. Behnke, Christopher R. Woodman, M. Harold Laughlin, Chester A. Ray, and Michael D. Delp: Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension
Am J Physiol Heart Circ Physiol 294: H1840-H1850, 2008. First published February 1, 2008; doi:10.1152/ajpheart.00692.2007 [Abstract] [Full Text] [PDF]

Joëlle Abi-Char, Saïd El-Haou, Elise Balse, Nathalie Neyroud, Roger Vranckx, Alain Coulombe, and Stéphane N. Hatem: The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes
Am J Physiol Heart Circ Physiol 294: H1851-H1861, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01045.2007 [Abstract] [Full Text] [PDF]

Linghua Kong, Martin Andrassy, Jong Sun Chang, Chun Huang, Tomohiro Asai, Matthias J. Szabolcs, Shunichi Homma, Rui Liu, Yu Shan Zou, Michael Leitges, Shi Du Yan, Ravichandran Ramasamy, Ann Marie Schmidt, and Shi-Fang Yan: PKCβ modulates ischemia-reperfusion injury in the heart
Am J Physiol Heart Circ Physiol 294: H1862-H1870, 2008. First published February 1, 2008; doi:10.1152/ajpheart.01346.2007 [Abstract] [Full Text] [PDF]

Tsung-Ming Lee, Chien-Chang Chen, Mei-Shu Lin, and Nen-Chung Chang: Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats
Am J Physiol Heart Circ Physiol 294: H1871-H1879, 2008. First published February 15, 2008; doi:10.1152/ajpheart.01129.2007 [Abstract] [Full Text] [PDF]

Zhongjie Sun, Mahajoub Bello-Roufai, and Xiuqing Wang: RNAi inhibition of mineralocorticoid receptors prevents the development of cold-induced hypertension
Am J Physiol Heart Circ Physiol 294: H1880-H1887, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01319.2007 [Abstract] [Full Text] [PDF]

Eric Plante, Dominic Lachance, Serge Champetier, Marie-Claude Drolet, Élise Roussel, Marie Arsenault, and Jacques Couet: Benefits of long-term β-blockade in experimental chronic aortic regurgitation
Am J Physiol Heart Circ Physiol 294: H1888-H1895, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01286.2007 [Abstract] [Full Text] [PDF]

Masahide Harada, Haruo Honjo, Masatoshi Yamazaki, Harumichi Nakagawa, Yuko S. Ishiguro, Yusuke Okuno, Takashi Ashihara, Ichiro Sakuma, Kaichiro Kamiya, and Itsuo Kodama: Moderate hypothermia increases the chance of spiral wave collision in favor of self-termination of ventricular tachycardia/fibrillation
Am J Physiol Heart Circ Physiol 294: H1896-H1905, 2008. First published February 29, 2008; doi:10.1152/ajpheart.00986.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures and Video]

Laurent Loufrani, Kevin Retailleau, Arnaud Bocquet, Odile Dumont, Kerstin Danker, Huguette Louis, Patrick Lacolley, and Daniel Henrion: Key role of ${alpha}$ ₁β₁-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries
Am J Physiol Heart Circ Physiol 294: H1906-H1913, 2008. First published February 1, 2008; doi:10.1152/ajpheart.00966.2006 [Abstract] [Full Text] [PDF]

Silvia Bertuglia: Intermittent hypoxia modulates nitric oxide-dependent vasodilation and capillary perfusion during ischemia-reperfusion-induced damage
Am J Physiol Heart Circ Physiol 294: H1914-H1922, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01371.2007 [Abstract] [Full Text] [PDF]

Nuria Villalba, Edgaras Stankevicius, Ulf Simonsen, and Dolores Prieto: Rho kinase is involved in Ca²⁺ entry of rat penile small arteries
Am J Physiol Heart Circ Physiol 294: H1923-H1932, 2008. First published January 25, 2008; doi:10.1152/ajpheart.01221.2007 [Abstract] [Full Text] [PDF]

Yeshao Wen, Jiali Gu, George E. Vandenhoff, Xiaoping Liu, and Jerry L. Nadler: Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages
Am J Physiol Heart Circ Physiol 294: H1933-H1938, 2008. First published February 22, 2008; doi:10.1152/ajpheart.00260.2007 [Abstract] [Full Text] [PDF]

Bradley M. Palmer, Yuan Wang, Polakit Teekakirikul, J. Travis Hinson, Diane Fatkin, Stacy Strouse, Peter VanBuren, Christine E. Seidman, J. G. Seidman, and David W. Maughan: Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex
Am J Physiol Heart Circ Physiol 294: H1939-H1947, 2008. First published February 15, 2008; doi:10.1152/ajpheart.00644.2007 [Abstract] [Full Text] [PDF]

Gudrun H. Borchert, Mike Giggey, Frantisek Kolar, Tak Ming Wong, Peter H. Backx, and Pablo V. Escriba: 2-Hydroxyoleic acid affects cardiomyocyte [Ca²⁺]_i transient and contractility in a region-dependent manner
Am J Physiol Heart Circ Physiol 294: H1948-H1955, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01209.2007 [Abstract] [Full Text] [PDF]

Holly R. Middlekauff, Josephine Chiu, Michele A. Hamilton, Gregg C. Fonarow, W. Robb MacLellan, Antoine Hage, Jaime Moriguchi, and Jignesh Patel: Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure
Am J Physiol Heart Circ Physiol 294: H1956-H1962, 2008. First published February 22, 2008; doi:10.1152/ajpheart.01304.2007 [Abstract] [Full Text] [PDF]

Rick E. Carlson, Brett S. Kirby, Wyatt F. Voyles, and Frank A. Dinenno: Evidence for impaired skeletal muscle contraction-induced rapid vasodilation in aging humans
Am J Physiol Heart Circ Physiol 294: H1963-H1970, 2008. First published February 29, 2008; doi:10.1152/ajpheart.01084.2007 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: Rotigaptide prevents ischemia-induced dephosphorylation of connexin43 in cardiac gap junctions. Confocal immunofluorescence images show no change in the distribution, pattern, or quantity of Cx43 signal in rotigaptide-treated hearts during ischemia. See Kjølbye AL, Dikshteyn M, Eloff BC, Deschênes I, Rosenbaum DS. Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans. Am J Physiol Heart Circ Physiol 294: H41–H49, 2008.