AJP - Heart and Circulatory Physiology -- Table of Contents (December 1 2008, 295 [6])

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EDITORIAL FOCUS:

Walter N. Durán: The double-edge sword of TNF- ${alpha}$ in ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol 295: H2221-H2222, 2008. First published October 10, 2008; doi:10.1152/ajpheart.01050.2008 [Full Text] [PDF]

TRANSLATIONAL PHYSIOLOGY:

David J. Chess, Wenhong Xu, Ramzi Khairallah, Karen M. O'Shea, Willem J. Kop, Agnes M. Azimzadeh, and William C. Stanley: The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet
Am J Physiol Heart Circ Physiol 295: H2223-H2230, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00563.2008 [Abstract] [Full Text] [PDF]

Pierre-Henri Rolland, Pascal de Lagausie, Euletheris Stathopoulos, Olivier Leprètre, Gilles Viudes, Guillaume Gorincour, Géraldine Hery, Catherine de Magnée, Olivier Paut, and Jean-Michel Guys: Phasic hemodynamics and reverse blood flows in the aortic isthmus and pulmonary arteries of preterm lambs with pulmonary vascular dysfunction
Am J Physiol Heart Circ Physiol 295: H2231-H2241, 2008. First published September 26, 2008; doi:10.1152/ajpheart.00410.2008 [Abstract] [Full Text] [PDF]

Xue Gao, Hanrui Zhang, Souad Belmadani, Junxi Wu, Xiangbin Xu, Howard Elford, Barry J. Potter, and Cuihua Zhang: Role of TNF- ${alpha}$ -induced reactive oxygen species in endothelial dysfunction during reperfusion injury
Am J Physiol Heart Circ Physiol 295: H2242-H2249, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00587.2008 [Abstract] [Full Text] [PDF]

ARTICLES:

Qi Hao, Hua Su, Douglas A. Marchuk, Radoslaw Rola, Yongqiang Wang, Weizhong Liu, William L. Young, and Guo-Yuan Yang: Increased tissue perfusion promotes capillary dysplasia in the ALK1-deficient mouse brain following VEGF stimulation
Am J Physiol Heart Circ Physiol 295: H2250-H2256, 2008. First published October 3, 2008; doi:10.1152/ajpheart.00083.2008 [Abstract] [Full Text] [PDF]

Irina A. Potapova, Sergey V. Doronin, Damon J. Kelly, Amy B. Rosen, Adam J. T. Schuldt, Zhongju Lu, Paul V. Kochupura, Richard B. Robinson, Michael R. Rosen, Peter R. Brink, Glenn R. Gaudette, and Ira S. Cohen: Enhanced recovery of mechanical function in the canine heart by seeding an extracellular matrix patch with mesenchymal stem cells committed to a cardiac lineage
Am J Physiol Heart Circ Physiol 295: H2257-H2263, 2008. First published October 3, 2008; doi:10.1152/ajpheart.00219.2008 [Abstract] [Full Text] [PDF]

Katja E. Odening, Omar Hyder, Leonard Chaves, Lorraine Schofield, Michael Brunner, Malcolm Kirk, Manfred Zehender, Xuwen Peng, and Gideon Koren: Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization
Am J Physiol Heart Circ Physiol 295: H2264-H2272, 2008. First published October 3, 2008; doi:10.1152/ajpheart.00680.2008 [Abstract] [Full Text] [PDF]

Kwangdeok Lee, Gerald M. Saidel, and Marc S. Penn: Permeability change of arterial endothelium is an age-dependent function of lesion size in apolipoprotein E-null mice
Am J Physiol Heart Circ Physiol 295: H2273-H2279, 2008. First published October 3, 2008; doi:10.1152/ajpheart.00242.2008 [Abstract] [Full Text] [PDF]

Amanda J. LeBlanc, Robert D. Shipley, Lori S. Kang, and Judy M. Muller-Delp: Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles
Am J Physiol Heart Circ Physiol 295: H2280-H2288, 2008. First published October 3, 2008; doi:10.1152/ajpheart.00541.2008 [Abstract] [Full Text] [PDF]

Elisha R. Injeti, Renan J. Sandoval, James M. Williams, Alexander V. Smolensky, Lincoln E. Ford, and William J. Pearce: Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries
Am J Physiol Heart Circ Physiol 295: H2289-H2298, 2008. First published October 3, 2008; doi:10.1152/ajpheart.00606.2008 [Abstract] [Full Text] [PDF]

Silvia M. Arribas, Ana M. Briones, Catherine Bellingham, M. Carmen González, Mercedes Salaices, Kela Liu, Yanting Wang, and Aleksander Hinek: Heightened aberrant deposition of hard-wearing elastin in conduit arteries of prehypertensive SHR is associated with increased stiffness and inward remodeling
Am J Physiol Heart Circ Physiol 295: H2299-H2307, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00155.2008 [Abstract] [Full Text] [PDF] [Supplemental Video]

Troy A. Markel, Yue Wang, Jeremy L. Herrmann, Paul R. Crisostomo, Meijing Wang, Nathan M. Novotny, Christine M. Herring, Jiangning Tan, Tim Lahm, and Daniel R. Meldrum: VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function
Am J Physiol Heart Circ Physiol 295: H2308-H2314, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00565.2008 [Abstract] [Full Text] [PDF]

Aaron K. Olson, Outi M. Hyyti, Gordon A. Cohen, Xue-Han Ning, Martin Sadilek, Nancy Isern, and Michael A. Portman: Superior cardiac function via anaplerotic pyruvate in the immature swine heart after cardiopulmonary bypass and reperfusion
Am J Physiol Heart Circ Physiol 295: H2315-H2320, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00739.2008 [Abstract] [Full Text] [PDF]

Betty Pat, Cheryl Killingsworth, Thomas Denney, Junying Zheng, Pamela Powell, Michael Tillson, A. Ray Dillon, and Louis J. Dell'Italia: Dissociation between cardiomyocyte function and remodeling with β-adrenergic receptor blockade in isolated canine mitral regurgitation
Am J Physiol Heart Circ Physiol 295: H2321-H2327, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00746.2008 [Abstract] [Full Text] [PDF]

Zequan Yang, Joel Linden, Stuart S. Berr, Irving L. Kron, George A. Beller, and Brent A. French: Timing of adenosine 2A receptor stimulation relative to reperfusion has differential effects on infarct size and cardiac function as assessed in mice by MRI
Am J Physiol Heart Circ Physiol 295: H2328-H2335, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00091.2008 [Abstract] [Full Text] [PDF]

Stefano Rossi, Silvana Baruffi, Andrea Bertuzzi, Michele Miragoli, Domenico Corradi, Roberta Maestri, Rossella Alinovi, Antonio Mutti, Ezio Musso, Andrea Sgoifo, Donatella Brisinda, Riccardo Fenici, and Emilio Macchi: Ventricular activation is impaired in aged rat hearts
Am J Physiol Heart Circ Physiol 295: H2336-H2347, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00517.2008 [Abstract] [Full Text] [PDF]

Ken Shinmura, Kayoko Tamaki, and Roberto Bolli: Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1
Am J Physiol Heart Circ Physiol 295: H2348-H2355, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00602.2008 [Abstract] [Full Text] [PDF]

Marek Malik, Katerina Hnatkova, Tomas Novotny, and Georg Schmidt: Subject-specific profiles of QT/RR hysteresis
Am J Physiol Heart Circ Physiol 295: H2356-H2363, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00625.2008 [Abstract] [Full Text] [PDF]

James G. Dobson, Jr., Lynne G. Shea, and Richard A. Fenton: Adenosine A_2A and β-adrenergic calcium transient and contractile responses in rat ventricular myocytes
Am J Physiol Heart Circ Physiol 295: H2364-H2372, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00927.2008 [Abstract] [Full Text] [PDF]

Patricia E. Gallagher, Carlos M. Ferrario, and E. Ann Tallant: Regulation of ACE2 in cardiac myocytes and fibroblasts
Am J Physiol Heart Circ Physiol 295: H2373-H2379, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00426.2008 [Abstract] [Full Text] [PDF]

Kevin S. Heffernan, Sae Young Jae, Kenneth R. Wilund, Jeffrey A. Woods, and Bo Fernhall: Racial differences in central blood pressure and vascular function in young men
Am J Physiol Heart Circ Physiol 295: H2380-H2387, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00902.2008 [Abstract] [Full Text] [PDF]

Sadaf S. Ahanchi, Vinit N. Varu, Nick D. Tsihlis, Janet Martinez, Charles G. Pearce, Muneera R. Kapadia, Qun Jiang, Joseph E. Saavedra, Larry K. Keefer, Joseph A. Hrabie, and Melina R. Kibbe: Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome
Am J Physiol Heart Circ Physiol 295: H2388-H2398, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00185.2008 [Abstract] [Full Text] [PDF]

Xinwen Wang, Hong Chai, Zehao Wang, Peter H. Lin, Qizhi Yao, and Changyi Chen: Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells
Am J Physiol Heart Circ Physiol 295: H2399-H2408, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00238.2008 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Diego López, Antonio Rodríguez-Sinovas, Luis Agulló, Javier Inserte, Alberto Cabestrero, and David García-Dorado: Acidic reoxygenation protects against endothelial dysfunction in rat aortic rings submitted to simulated ischemia
Am J Physiol Heart Circ Physiol 295: H2409-H2416, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00409.2008 [Abstract] [Full Text] [PDF]

Anar Dossumbekova, Evgeny V. Berdyshev, Irina Gorshkova, Zuohui Shao, Changqing Li, Phillip Long, Atul Joshi, Viswanathan Natarajan, and Terry L. Vanden Hoek: Akt activates NOS3 and separately restores barrier integrity in H₂O₂-stressed human cardiac microvascular endothelium
Am J Physiol Heart Circ Physiol 295: H2417-H2426, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00501.2008 [Abstract] [Full Text] [PDF]

Kartik S. Sundareswaran, Kerem Pekkan, Lakshmi P. Dasi, Kevin Whitehead, Shiva Sharma, Kirk R. Kanter, Mark A. Fogel, and Ajit P. Yoganathan: The total cavopulmonary connection resistance: a significant impact on single ventricle hemodynamics at rest and exercise
Am J Physiol Heart Circ Physiol 295: H2427-H2435, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00628.2008 [Abstract] [Full Text] [PDF]

Yumei Ye, Yu Lin, Saraswathy Manickavasagam, J. Regino Perez-Polo, Brian C. Tieu, and Yochai Birnbaum: Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice
Am J Physiol Heart Circ Physiol 295: H2436-H2446, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00690.2008 [Abstract] [Full Text] [PDF]

Misa Yoshimoto, Erica A. Wehrwein, Martin Novotny, Greg M. Swain, David L. Kreulen, and John W. Osborn: Effect of stellate ganglionectomy on basal cardiovascular function and responses to β₁-adrenoceptor blockade in the rat
Am J Physiol Heart Circ Physiol 295: H2447-H2454, 2008. First published October 17, 2008; doi:10.1152/ajpheart.00958.2008 [Abstract] [Full Text] [PDF]

Kathryn M. Dunn, Marija Renic, Averia K. Flasch, David R. Harder, John Falck, and Richard J. Roman: Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats
Am J Physiol Heart Circ Physiol 295: H2455-H2465, 2008. First published October 24, 2008; doi:10.1152/ajpheart.00512.2008 [Abstract] [Full Text] [PDF]

François-Xavier Boittin, Françoise Gribi, Karima Serir, and Jean-Louis Bény: Ca²⁺-independent PLA₂ controls endothelial store-operated Ca²⁺ entry and vascular tone in intact aorta
Am J Physiol Heart Circ Physiol 295: H2466-H2474, 2008. First published October 24, 2008; doi:10.1152/ajpheart.00639.2008 [Abstract] [Full Text] [PDF]

Sharad Rastogi, Makoto Imai, Victor G. Sharov, Sudhish Mishra, and Hani N. Sabbah: Darbepoetin- ${alpha}$ prevents progressive left ventricular dysfunction and remodeling in nonanemic dogs with heart failure
Am J Physiol Heart Circ Physiol 295: H2475-H2482, 2008. First published October 24, 2008; doi:10.1152/ajpheart.00074.2008 [Abstract] [Full Text] [PDF]

J. Michael O'Donnell, Aaron Fields, Xianyao Xu, Shamim A. K. Chowdhury, David L. Geenen, and Jian Bi: Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo
Am J Physiol Heart Circ Physiol 295: H2483-H2494, 2008. First published October 24, 2008; doi:10.1152/ajpheart.01023.2008 [Abstract] [Full Text] [PDF]

Michael J. Raher, Helene B. Thibault, Emmanuel S. Buys, Darshini Kuruppu, Nobuyuki Shimizu, Anna-Liisa Brownell, Sarah L. Blake, Jennifer Rieusset, Masao Kaneki, Genevieve Derumeaux, Michael H. Picard, Kenneth D. Bloch, and Marielle Scherrer-Crosbie: A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload
Am J Physiol Heart Circ Physiol 295: H2495-H2502, 2008. First published October 31, 2008; doi:10.1152/ajpheart.00139.2008 [Abstract] [Full Text] [PDF]

L. S. A. Capettini, S. F. Cortes, M. A. Gomes, G. A. B. Silva, J. L. Pesquero, M. J. Lopes, M. M. Teixeira, and V. S. Lemos: Neuronal nitric oxide synthase-derived hydrogen peroxide is a major endothelium-dependent relaxing factor
Am J Physiol Heart Circ Physiol 295: H2503-H2511, 2008. First published October 24, 2008; doi:10.1152/ajpheart.00731.2008 [Abstract] [Full Text] [PDF]

Satoshi Asada, Tomosaburo Takahashi, Koji Isodono, Atsuo Adachi, Hiroko Imoto, Takehiro Ogata, Tomomi Ueyama, Hiroaki Matsubara, and Hidemasa Oh: Downregulation of Dicer expression by serum withdrawal sensitizes human endothelial cells to apoptosis
Am J Physiol Heart Circ Physiol 295: H2512-H2521, 2008. First published October 31, 2008; doi:10.1152/ajpheart.00233.2008 [Abstract] [Full Text] [PDF]

Sunil Baldwa, Muzamil Rana, John M. Canty, Jr., and James A. Fallavollita: Comparison of thallium deposition with segmental perfusion in pigs with chronic hibernating myocardium
Am J Physiol Heart Circ Physiol 295: H2522-H2529, 2008. First published November 7, 2008; doi:10.1152/ajpheart.00761.2008 [Abstract] [Full Text] [PDF]

Liang-Wu Fu, Andrew Phan, and John C. Longhurst: Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A₂?
Am J Physiol Heart Circ Physiol 295: H2530-H2540, 2008. First published October 24, 2008; doi:10.1152/ajpheart.00790.2008 [Abstract] [Full Text] [PDF]

Jinbao Liu, Hanqiao Zheng, Mingxin Tang, Youn-Chul Ryu, and Xuejun Wang: A therapeutic dose of doxorubicin activates ubiquitin-proteasome system-mediated proteolysis by acting on both the ubiquitination apparatus and proteasome
Am J Physiol Heart Circ Physiol 295: H2541-H2550, 2008. First published October 31, 2008; doi:10.1152/ajpheart.01052.2008 [Abstract] [Full Text] [PDF]

Leonid Shmuylovich and Sándor J. Kovács: Stiffness and relaxation components of the exponential and logistic time constants may be used to derive a load-independent index of isovolumic pressure decay
Am J Physiol Heart Circ Physiol 295: H2551-H2559, 2008. First published October 24, 2008; doi:10.1152/ajpheart.00780.2008 [Abstract] [Full Text] [PDF]

INNOVATIVE METHODOLOGY:

Robert G. Turcott and Todd J. Pavek: Hemodynamic sensing using subcutaneous photoplethysmography
Am J Physiol Heart Circ Physiol 295: H2560-H2572, 2008. First published October 10, 2008; doi:10.1152/ajpheart.00574.2008 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: Masson's trichrome of the normal external jugular vein shows that the normal extracellular matrix (blue color) is located within the media and adventitia. See Misra S, Fu AA, Puggioni A, Karimi KM, Mandrekar JN, Glockner JF, Juncos LA, Anwer B, McGuire AM, Mukhopadhyay D. Increased shear stress with upregulation of VEGF-A and its receptors and MMP-2, MMP-9, and TIMP-1 in venous stenosis of hemodialysis grafts. Am J Physiol Heart Circ Physiol 294: H2219–H2230, 2008.