Table 3.

By ECM and adhesion molecule gene array analysis, 10 genes were increased and 24 genes decreased in TG LV

WTTGP
↑ in TG
    Ctnna195.67 ± 4.73176.21 ± 11.830.0006
    Cdh252.23 ± 10.89103.52 ± 11.090.0049
    Emilin112.03 ± 1.0419.65 ± 2.110.0033
    Itga40.63 ± 0.110.77 ± 0.050.0434
    Itgb22.81 ± 0.294.88 ± 0.550.0030
    Lama27.19 ± 0.4911.07 ± 1.250.0085
    Lamb33.43 ± 0.214.29 ± 0.300.0270
    Mmp80.09 ± 0.020.22 ± 0.040.0031
    Mmp110.59 ± 0.090.71 ± 0.040.0434
    Sparc97.44 ± 7.41123.72 ± 3.660.0117
↓ in TG
    Ctnnb1176.48 ± 6.17144.32 ± 3.890.0008
    Cdh30.043 ± 0.0040.022 ± 0.0020.0016
    Col1a149.44 ± 4.9728.00 ± 2.470.0009
    Col3a182.11 ± 10.2245.05 ± 5.400.0090
    Col4a31.50 ± 0.140.63 ± 0.110.0003
    Col5a121.92 ± 2.1014.43 ± 1.360.0121
    Ctgf81.04 ± 15.2345.73 ± 5.240.0434
    Hapln10.557 ± 0.1830.033 ± 0.0050.0117
    Hc0.14 ± 0.030.05 ± 0.020.0434
    Icam119.33 ± 1.919.17 ± 0.66<0.0001
    Itga35.58 ± 0.693.27 ± 0.130.0005
    Itgae0.75 ± 0.150.37 ± 0.080.0495
    Itgb34.60 ± 0.541.67 ± 0.13<0.0001
    Itgb40.33 ± 0.040.15 ± 0.01<0.0001
    Lama33.00 ± 0.371.54 ± 0.160.0021
    Lamc166.97 ± 4.7951.86 ± 1.920.0266
    Mmp90.54 ± 0.100.25 ± 0.060.0316
    Mmp1411.05 ± 0.885.45 ± 0.49<0.0001
    Ncam13.63 ± 0.701.28 ± 0.140.0434
    Ncam20.053 ± 0.0090.026 ± 0.0040.0067
    Pecam1126.8 ± 8.8888.31 ± 6.190.0038
    Thbs165.47 ± 13.878.60 ± 1.340.0003
    Thbs36.82 ± 0.803.90 ± 0.300.0031
    Tnc2.27 ± 0.301.18 ± 0.140.0085
    Vcam10.67 ± 1.455.87 ± 0.340.0266
  • Data are expressed as means ± SE. Gene expression was normalized to hypoxanthine-guanine phosphoribosyltransferase 1 and shown as 2−ΔCt × 100 units. All genes listed were P < 0.05 vs. WT (WT, n = 10; TG, n = 8). Underlines, angiogenic genes.