Table 1.

Changes in body mass of animals

Time PointControlRadiatedSignificance (P value)
Baseline27.4 ± 0.5 (29)27.7 ± 0.4 (16)NS (0.590)
18 Gy28.7 ± 0.5 (29)25.7 ± 1.2 (16)(0.008)**
36 Gy29.0 ± 0.5 (29)25.3 ± 1.0 (16)(<0.001)***
1 mo post-WBRT29.3 ± 0.5 (29)26.2 ± 1.3 (16)(0.006)**
End of study
    Normoxia30.0 ± 0.7 (13)28.3 ± 1.0 (8)NS (0.157)
    Hypoxia28.6 ± 0.6 (16)27.1 ± 0.4 (8)NS (0.133)
  • Data represent means ± SE; for control and radiated groups, no. of animals is in parentheses. Animals were selected for body mass measurement at each major step of the experiment. Time points shown represent: before commencement of whole brain radiation therapy (WBRT) (baseline), after a cumulative dose of 18 Gy, after completion of the cumulative series of irradiation (36 Gy), 1 mo post-WBRT, and at the end of the hypoxia or normoxia treatment. NS, not significant.

  • ** P < 0.01 and

  • *** P < 0.001.