Table 1.

Echocardiography of 1-day-old WT and mutant mice

ParametersRyr2+/+Ryr2+/ADARyr2ADA/ADA
HR, beats/min490 ± 13445 ± 31353 ± 12*
LVEDD, mm1.29 ± 0.071.54 ± 0.091.61 ± 0.15
LVESD, mm0.65 ± 0.080.76 ± 0.081.09 ± 0.13
FS, %50.0 ± 5.051.2 ± 3.533.6 ± 2.3*
IVSD, mm0.44 ± 0.050.51 ± 0.030.48 ± 0.04
IVSS, mm0.77 ± 0.120.82 ± 0.040.67 ± 0.04
LVPWD, mm0.49 ± 0.090.40 ± 0.010.50 ± 0.05
LVPWS, mm0.75 ± 0.080.76 ± 0.070.67 ± 0.04
  • Values are means ± SE; n = 3, 5, and 9 mice for Ryr2+/+, Ryr2+/ADA, and Ryr2ADA/ADA groups, respectively. WT, wild-type; HR, heart rate; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; FS, fractional shortening (LVEDD – LVESD)/LVEDD); IVSD, interventricular septum diastolic thickness; IVSS, interventricular septum systolic thickness; LVPWD, left ventricular posterior wall diastolic thickness; LVPWS, left ventricular posterior wall systolic thickness.

  • * P < 0.05 compared with Ryr2+/+.