Table 1.

IA-to-AR ratio for different protocols

nAR, %LV IA/AR
Control 860 ± 5 62 ± 5
Control + HOE-140 650 ± 9 58 ± 6
CAO 6 52 ± 737 ± 3*
CAO + HOE-140 6 55 ± 571 ± 6
MAO 6 52 ± 735 ± 5*
MAO + HOE-140 6 49 ± 865 ± 7
Saline 3 53 ± 1452 ± 4
Bradykinin 7 55 ± 526 ± 3*
Bradykinin + Hex 6 50 ± 567 ± 4
  • Values are means ± SE; n = no. of rats studied. AR, area at risk; IA, infarct area; CAO, classic preconditioning by coronary artery occlusion; MAO, remote preconditioning by mesenteric artery occlusion; HOE-140, Hoechst 140 pretreatment; Hex, hexamethonium pretreatment.

  • * Significant effect compared with control.

  • Significant effect of HOE-140 or Hex pretreatment on respective cardiac protection.