Table 1.

Subject characteristics

nBaseline1 yr% ChangeP Value, Within-Group Change, Baseline Vs. 1 yrP Value, Between-Groups Change
Weight, kg
    CR1278 (SD 8)68 (SD 9)−13.3 (SD 4.6)<0.00010.35
    Ex1377 (SD 11)68 (SD 8)−11.1 (SD 4.8)<0.0001
BMI, kg/m2
    CR1227 (SD 2)24 (SD 2)−11.1 (SD 4.8)<0.00010.22
    Ex1327 (SD 2)24 (SD 2)−13.3 (SD 4.6)<0.0001
EF, %
    CR1269 (SD 4)69 (SD 4)0.2 (SD 5.8)0.53*0.97
    Ex1169 (SD 5)69 (SD 5)0.9 (SD 7.0)0.75
LV mass, g
    CR12148 (SD 53)143 (SD 48)0.3 (SD 24.1)0.670.80
    Ex11144 (SD 48)144 (SD 43)2.5 (SD 25.1)0.96
SBP, mmHg
    CR12117 (SD 13)107 (SD 15)−7.9 (SD 11.4)0.030.01
    Ex13121 (SD 15)124 (SD 12)3.3 (SD 13.8)0.58
DBP, mmHg
    CR1267 (SD 10)61 (SD 9)−9.4 (SD 12.1)0.010.006
    Ex1368 (SD 10)70 (SD 10)5.6 (SD 16.2)0.34
Resting HR, beats/min
    CR1264 (SD 11)58 (SD 12)−9.0 (SD 11.6)0.160.90
    Ex1367 (SD 13)61 (SD 14)−8.7 (SD 17.8)0.15
  • Values are means (SD); n, number of subjects. Ejection fraction (EF) and left ventricular (LV) mass were only determined for 11 of the exercise group (Ex) subjects due to a lack of M-mode images for the other 2 subjects. CR, caloric restriction group; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate.

  • * P value based on Wilcoxon's signed rank test.

  • Data collected at 3, 6, and 9 mo are included in the analytical model although not presented in the table for brevity.