Table 3.

Indexes of longitudinal LV diastolic function derived from Doppler tissue imaging of the lateral aspect of the mitral annulus

nBaseline1 yr%ChangeP Value, Within-Group ChangeP Value, Between-Groups Change
E′, cm/s
    CR810 (SD 2)11 (SD 2)7 (SD 12)0.120.48
    Ex910 (SD 1)11 (SD 2)3 (SD 13)0.57
A′, cm/s
    CR810 (SD 2)11 (SD 2)12 (SD 27)0.360.75
    Ex911 (SD 1)11 (SD 3)7 (SD 22)0.50*
E′/A′
    CR81.1 (SD 0.3)1.1 (SD 0.4)0.1 (SD 29.6)0.940.82
    Ex91.0 (SD 0.2)1.0 (SD 0.3)−0.5 (SD 19.5)0.84
E/E′
    CR87.9 (SD 3.4)7.2 (SD 2.6)−4.4 (SD 17.9)0.310.74
    Ex97.4 (SD 2.2)6.8 (SD 1.8)−6.7 (SD 18.7)0.22
c′, g/s
    CR823.7 (SD 3.9)21.5 (SD 3.5)−8.5 (SD 13.2)0.110.09
    Ex924.2 (SD 5.2)24.5 (SD 4.2)3.4 (SD 17.1)0.79
k′, g/s2
    CR8337 (SD 74)372 (SD 104)10.9 (SD 23.5)0.270.55
    Ex9374 (SD 87)354 (SD 71)−0.3 (SD 33.9)0.63
xo, cm
    CR80.9 (SD 0.1)1.1 (SD 0.1)13.2 (SD 17.5)0.080.46
    Ex91.0 (SD 0.1)1.1 (SD 0.2)4.7 (SD 13.9)0.30
kxo, g·cm/s2
    CR8320 (SD 70)401 (SD 146)27.7 (SD 41.5)0.150.67
    Ex9375 (SD 93)378 (SD 120)6.4 (SD 44.6)0.94
1/2kxo2, g·cm2/s2
    CR8155 (SD 38)220 (SD 107)47.4 (SD 63.7)0.130.73
    Ex9191 (SD 57)212 (SD 96)16.8 (SD 59.7)0.55
  • Values are means (SD); n, number of subjects. Diastolic filling parameters and computed indexes were not determined for 1 subject in the CR and 1 subject in the Ex group due to inadequate image quality. E′ and A′, peak early and late mitral annular velocity, respectively; c′, longitudinal damping constant (i.e., longitudinal relaxation/viscosity); k′, longitudinal spring constant (i.e., longitudinal stiffness); xo, stored longitudinal elastic strain; kxo, peak longitudinal force; kxo2, peak longitudinal stored strain energy.

  • * P value based on Wilcoxon's signed rank test.